This $600,000 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research project between The Ohio State University and Wayne State University. The project aims to understand the fundamental photochemical processes in ruthenium(II) complexes, with a focus on investigating dual-activity compounds that can generate cytotoxic singlet oxygen and undergo photoinduced ligand exchange. The research will employ ultrafast spectroscopic techniques and the synthesis of new ruthenium complexes to elucidate the mechanisms governing the excited-state dynamics and photosubstitution reactions. The project also has an educational component, providing training opportunities for students underrepresented in science. As part of the collaboration, Wayne State University will synthesize new ligands and ruthenium complexes, and work with the lead PI at Ohio State to evaluate their photochemical reactivity. This award reflects NSF's mission to advance scientific knowledge and support innovative research with potential applications in areas like solar energy conversion and phototherapeutic drug delivery.
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