The University of California, San Diego (UCSD) was awarded a $587,425 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to develop the first dual-modality super-resolution microscopy system, termed Dual-Modality Localized Plasmonic Structured Illumination Microscopy (DM-LPSIM). This new imaging technology will enable simultaneous high-speed super-resolution fluorescence and label-free scattering imaging at the 50-nanometer scale. The DM-LPSIM system leverages engineered illumination patterns and nanoplasmonic substrates to achieve this unprecedented imaging capability, which has the potential to significantly advance the study of complex biological systems and interactions at the nanoscale. The award, with a performance period from Apr 1, 2024 to Mar 31, 2027, will support the development of this transformative microscopy tool and related education/outreach initiatives to engage students and the broader community.
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