This $525,177 Project Grant awarded by the National Science Foundation (NSF) Division of Chemistry's Chemical Structure, Dynamics & Mechanisms B Program supports the development of new coordination complexes that functionally mimic the antioxidant enzyme catalase. Auburn University is leading the research, which lies at the interface of biochemistry, organic chemistry, and inorganic chemistry. The goal is to create manganese, iron, and zinc complexes with redox-active organic ligands that can efficiently catalyze the conversion of hydrogen peroxide to water and oxygen, potentially supplementing the body's defenses against oxidative stress associated with various disorders. The work includes mechanistic studies and evaluating modifications to the ligand structure to optimize catalase-like activity. The award also supports outreach efforts to engage more undergraduate students in scientific research through a local chemistry symposium and a research experiences program. The project period runs from September 1, 2024 through August 31, 2027.
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