The Regents of the University of California, San Francisco (UCSF) received a $550,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an advanced cryopreservation system for complex bioengineered tissues. The project aims to determine the thermodynamic and biological parameters needed for isochoric supercooling cryopreservation of three-dimensional tissues within a microgravity-optimized...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $306,852 to Mitegen, LLC, a manufacturer of advanced scientific instruments and technologies located in Lansing, New York. The funding will support the development and validation of innovative cryopreservation technology that automates the soaking, cooling, and warming processes for small biological samples such as oocytes and...
This federal Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $940,821 to Cryocrate LLC, a for-profit biotech company based in Columbia, Missouri, to develop a first-in-class biocompatible and efficient cryopreservation technology platform for cell-based therapeutics in regenerative medicine and drug discovery. The key objectives of this project are: (I) Producing the company's proprietary Odinsol cryopreservation medium...
This $558,370 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports fundamental research into the use of energized fields, such as electrical, magnetic, and ultrasound, in combination with the freeze casting manufacturing process. The goal is to develop a better understanding of how these energized fields can be leveraged to tailor the microstructure and properties of porous materials produced through freeze casting. The research will...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $507,517 to the University of Washington to develop novel, synthetic therapies for stabilizing trauma victims in the critical "golden hour" after injury. The key objectives are to engineer low volume resuscitants that provide fluid resuscitation...
This Project Grant award of $304,436 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) aims to advance fundamental knowledge needed to scale up the use of tunable high-frequency microwave heating for pharmaceutical and biologics manufacturing. The key objectives are to develop experimental methods for estimating dielectric properties of frozen materials, identify physics-based models for system simulation, and implement control...
This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant award, totaling $920,715, aims to elucidate the roles of gravity on the freezing dynamics of sessile drops in the presence of soluble and insoluble particles. The research will be conducted at the University of Illinois and involve several key tasks: fabricating samples and solutions for experiments on the International Space Station (ISS), coordinating with NASA to prepare the experimental rig, overseeing...
This $350,000 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program, supports the collaborative development and sharing of high-resolution in situ 3D cryogenic workflows to transform plant cell biology research. The goal is to overcome challenges in cryopreservation of plant tissue samples to enable unprecedented observation of plant cell structures and functions in their native state using advanced volume electron microscopy techniques....
This $305,939 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research to develop a new class of fiber-reinforced plastic (FRP) composites based on vitrimer polymers. The key objectives are to: Elucidate the balance between healability and glass transition temperature (Tg) of vitrimer polymers to enhance mechanical properties while maintaining the ability to repeatedly heal fatigue damage. Explore the...
This federal Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $2,011,109.00 to Cryocrate LLC, a for-profit limited liability company based in Columbia, Missouri, to develop and secure FDA clearance for their novel cryopreservation technology, Odinsol. The key objectives are to establish GMP production capabilities and conduct in vitro and in vivo evaluations to demonstrate the biocompatibility and...