Project Grant 2344169
- This $220,848 two-year Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund the development of new approaches for spatial transcriptome analysis in plants under the Biological Sciences program (CFDA 47.074). The awardee, Virginia Polytechnic Institute and State University, will leverage existing fluorescent reporter gene lines to perform single-cell RNA sequencing and fluorescent imaging of the meristematic region of plant roots. Machine...
- The National Science Foundation awarded a $179,150 Project Grant to the Donald Danforth Plant Science Center under the Biological Sciences federal grant program (CFDA 47.074) for the period of June 15, 2022 through May 31, 2024. The award will support the development of new computational tools and methods to translate single-cell RNA sequencing data into an ultra-high resolution 3D spatial map of gene expression in plant roots. Specifically, the grantee will leverage existing fluorescent...
- This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
- The National Science Foundation awarded a $199,918 Project Grant to the University of Michigan under the Biological Sciences federal grant program (CFDA 47.074) for the period of June 15, 2022 through May 31, 2024. The award will support the development of new computational tools and methods to map single-cell RNA sequencing data onto 3D spatial models of plant roots at ultra-high resolution. Researchers will leverage existing fluorescent reporter gene lines in Arabidopsis to perform...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $649,999 to Duke University to conduct collaborative research on transcription factor binding sites in plant organ formation. The goal is to create a semi-automated system to analyze gene activity across different plant organ types, such as roots, leaves, and flowers. The research will compare two plant species, define the role of a cell signaling pathway on gene function in...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $300,000 in funding to Western University of Health Sciences to conduct collaborative research on the variability and regulation of the plant polyadenylation complex. The research aims to better understand how this complex mediates gene expression and plant responses to environmental and developmental cues, with the goal of improving our knowledge of crop plant growth,...
- This $750,000 Project Grant awarded by the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program will support a collaborative research effort between UNC-Chapel Hill and international partners to conduct a comparative high-resolution analysis of transcription factor binding sites in plant organ formation. The primary objectives are to develop a semi-automated system to study gene activity across different plant organ types, compare findings across two plant species, and...
- This $741,002 federal Project Grant award from the National Science Foundation's Biological Sciences program supports the development of a novel machine learning framework for analyzing large-scale, multi-modal single-cell biological data. The project aims to construct advanced computational tools and user-friendly software to enable more effective extraction of insights and knowledge from complex single-cell datasets spanning genomics, transcriptomics, epigenomics, and proteomics. The...
- The National Science Foundation (NSF) awarded a $259,157 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to Worcester Polytechnic Institute (WPI) for the collaborative research project "TOOLS4CELLS: AN INDUCIBLE DEGRON TOOL FOR PLANT CELL BIOLOGY." The project aims to expand the capabilities of a recently developed tool called E3 DART to control protein degradation in plants, providing the opportunity to manipulate the abundance of protein targets at the...
- This Project Grant award of $100,000 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) was provided to George Mason University to develop novel quantum algorithms for analyzing single-cell omics data. The project aims to build faster and more powerful computational tools for advancing the analysis of complex biological data, particularly from emerging single-cell studies, in order to accelerate scientific discovery. The work will formulate these computational...
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports the development of new computational tools for analyzing single-cell genomic data across diverse plant species. The $1,180,752 award to Virginia Polytechnic Institute & State University aims to address key challenges in plant single-cell transcriptomics, including determining known and novel cell types, enabling cross-species comparisons, and overcoming the lack of curated training data. The project team will develop methods for multi-reference-based cell annotation, generative models to improve single-cell data resolution, and educational materials to engage researchers and students in plant genomics data analytics. This work is expected to enhance understanding of cellular-level gene expression and function in plants, with applications in agriculture and plant biology research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 7/9/24 |