This is a $600,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Davis. The award supports research investigating the fundamental mechanisms underlying liquid-liquid phase separation and membrane remodeling in cell-like environments. The project aims to quantify the dynamics of phase coarsening, map relationships between intravesicular macromolecular crowding and membrane changes, and characterize the coupling between phase separation dynamics and membrane boundary in complex intravesicular media. The research involves a partnership between graduate students at UC Davis and undergraduate students at California State University, Sacramento, and will also be integrated into educational programs at both institutions. A $242,177 subaward to University Enterprises, Inc. at Sacramento State will support specific components of the research focused on the coupling of bulk and membrane phase separation in giant vesicle models.
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