The National Science Foundation (NSF) awarded a $162,510 Project Grant under the Computer and Information Science and Engineering (CFDA 47.070) program to the University of Oklahoma to develop algorithms for scalable inference and phylodynamic analysis of tumor haplotypes using low-coverage single-cell sequencing data. The goal is to create a phylodynamic framework to jointly infer cancer phylogenetic trees and evolutionary parameters from single-cell DNA sequencing data. This will enable cancer researchers to statistically and computationally evaluate the effects of genome alterations. The project also supports the development of cross-disciplinary curricula and bioinformatics training for diverse student cohorts at Georgia State University, the University of Connecticut, and UConn Health. The award period runs from July 1, 2023 to September 30, 2025.
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