The National Science Foundation (NSF) awarded a 5-year, $574,881 CAREER grant to The Washington University's Office of Sponsored Research Services Division to investigate the biomechanical consequences of localized defects in the aortic wall. The research aims to better understand the factors that contribute to aortic rupture using innovative mechanobiological, microstructural, and mechanical testing approaches. Specific objectives include a comprehensive biomechanical assessment of aortic wall defects and fatigue-induced failure using ex vivo and in vivo models, and developing a computational model of soft tissue failure. The project will also integrate an educational outreach program to provide K-6, university, and incarcerated adult students with opportunities to participate in STEAM activities related to optics, materials science, and cardiovascular health. This award, funded under NSF's Engineering program (CFDA 47.041), aims to advance the field's understanding of local soft tissue rupture mechanisms while promoting interest in interdisciplinary STEAM careers and enhancing diversity in the biomedical workforce.
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