This National Science Foundation (NSF) Project Grant award, funded under the Engineering program (CFDA 47.041), aims to decode how single-cell phenotypic heterogeneity arises and can be precisely controlled in T cells, a critical type of white blood cell for immune system function and cancer therapies. The $574,808 award, granted to Duke University, will leverage cutting-edge technologies including spatial proteomic multiplexed imaging, in vitro cell tracking, and engineered biomaterial...
This Project Grant award from the National Science Foundation (NSF) under the Social, Behavioral, and Economic Sciences (CFDA 47.075) program provides $250,000 to Old Dominion University Research Foundation (Odurf) to develop novel mRNA-based, distributed manufacturing technologies for producing chimeric antigen receptor (CAR) T-cell therapies. The key objectives are to: Theoretically and experimentally study protein expression and half-life of electroporated T-cells with mRNA molecules, and...
This $487,795 award from the National Science Foundation (NSF) Engineering grant program (CFDA 47.041) supports Arizona State University in developing innovative ex vivo models of the tumor microenvironment (TME). The project aims to mechanistically understand how biophysical cues and signaling between stromal and immune cells contribute to the transition of tumor cells into an invasive phenotype, as well as explore how stromal cell function induces pathway signatures in tumor cells leading to...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
This Project Grant award of $1,271,780.00 from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), supports research to develop small molecule adaptors for programming a universal chimeric antigen receptor (CAR) T cell therapy. The key objectives are to: 1) Develop small molecule adaptors to target the universal CAR to multiple antigens, including tumor cells and immunosuppressive cells; 2) Enhance targeting specificity using chemical switches...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will fund the development of a continuous monitoring system for therapeutic monoclonal antibodies (mAbs) using in situ regenerable aptamer sensors. The $379,730 award, granted to the University of North Carolina at Chapel Hill, aims to enable real-time measurement of mAb concentrations in the body, which would allow clinicians to appropriately dose patients for conditions such as cancer,...
This $508,785 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research at Columbia University to investigate how the chemical composition and mechanical properties of biomaterials can be optimized to improve the production and function of T cells for use in cancer immunotherapy. The project aims to gain fundamental knowledge on how nutrient transport, particularly oxygen availability, within these biomaterials affects T cell...
Northeastern University was awarded a $398,495 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the NSF Engineering program (CFDA 47.041). The grant will fund the development of a microfluidic device capable of sorting effective T cells from ineffective T cells for use in cell therapy products. The project aims to improve the biomanufacturing process for engineering immune cell therapies, with a focus on...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $304,733 to Selight, LLC, a woman-owned small business located in Madison, WI, aims to develop a novel optical metabolic flow cytometer instrument to screen T cell fitness for chimeric antigen receptor (CAR) T-cell therapy. The project's broader impact is a rapid diagnostic method to identify patients who will benefit most from CAR T-cell therapy, which can fail in 15-69% of...
The Trustees of the University of Pennsylvania received a $375,708 Project Grant award from the National Science Foundation to support the CAREER: SYSTEMS IMMUNOLOGY APPROACH TO MEMORY T CELL IMMUNE ENGINEERING project. The grant was awarded on June 1, 2021 under the NSF Engineering Program (CFDA 47.041) to fund research from June 2021 through June 2022. The project aims to apply systems immunology approaches to engineer memory T cell immune responses. As part of its mission to improve...