This National Science Foundation (NSF) Engineering Program project grant awarded to the Massachusetts Institute of Technology (MIT) provides $429,384 in funding to study how drug nanoparticles adhered to leukocyte (white blood cell) surfaces influence their mechanical properties and movement through microscale blood vessel networks. The 5-year research effort, from March 2024 to February 2029, will use a combination of biophysical models and microfluidic experiments to generate fundamental...
This $169,317 Project Grant was awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to the Marshall University Research Corporation (MURC) in Huntington, West Virginia. The funding will support research to investigate how exposure to silver nanoparticles, commonly used in consumer and medical products, can disrupt brain cell development and function. The project will use cultured neural cells and a worm model system to understand the molecular mechanisms by which...
The National Science Foundation (NSF) Directorate for Engineering awarded a $150,000 Project Grant to the University of Alabama in Huntsville (UAH) to support the development of new magnetic particle imaging tracers. The goal is to create superparamagnetic iron oxide nanoparticle clusters with controlled properties that can be used to improve magnetic particle imaging, a non-invasive medical imaging technique similar to MRI. Key objectives include designing and synthesizing poly(amino acid)...
The National Science Foundation (NSF) awarded a $325,164 CAREER grant under its Engineering program (CFDA 47.041) to the University of South Carolina (USC) to conduct multiscale simulations of iron oxide nanoparticle-protein electron transfer. The goal is to elucidate the fundamental mechanisms of these nano-bio interactions to enable more efficient environmental applications using coupled iron oxide nanoparticles and metal-reducing bacteria. The 2-year project will integrate computational...
This $138,673 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) under CFDA Program 47.041 "Engineering" aims to develop machine learning models to predict protein-nanoparticle interactions. The research team at Mississippi State University will characterize the protein corona that forms on nanoparticle surfaces and use this data to train machine learning algorithms that can predict which...
This National Science Foundation (NSF) Project Grant award under the Engineering (CFDA 47.041) program totaling $165,437 is funding research to visualize and characterize the motion and interaction of individual nanoparticles near surfaces. The awardee, Georgia Tech Research Corporation, will develop a workflow combining nanoscale microscopy with data-driven modeling to study how nanoparticles move and interact in heterogeneous environments, with applications in areas such as nanomedicine,...
The National Science Foundation awarded Nanoxort LLC a $256,000 Project Grant under the Engineering federal grant program (CFDA 47.041) for the period of March 15, 2021 through February 28, 2022. The grant funds the development of a novel size-changing, gadolinium-free contrast agent for magnetic resonance angiography. The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in engineering research. This award supports Nanoxort's...
This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems Project Grant award in the amount of $184,994 provides funding to the University of Rhode Island Research Office, doing business as URI - Research, from August 1, 2023 to July 31, 2026. The award supports a collaborative research project to advance Magnetic Particle Imaging (MPI), a non-invasive medical imaging technique similar to Magnetic Resonance Imaging. The project involves...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program supports the development of new classes of magnetic resonance imaging (MRI) contrast agents or probes based on iron coordination complexes. The University of Buffalo's Professor Janet Morrow and her team are working to design iron-based contrast agents that can produce a strong MRI signal. This includes developing both stabilized signal-producing iron agents and oxidation-responsive...
This $128,740 National Science Foundation (NSF) Project Grant award to Brown University, funded through the NSF Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) (CFDA 47.041 - Engineering), is supporting collaborative research to develop new magnetic particle imaging (MPI) tracer platforms. The key objectives are to create controlled clustering of superparamagnetic iron oxide nanoparticles using specialized polymers derived from natural amino acids, in order to...
This National Science Foundation (NSF) Engineering program Project Grant awarded to West Virginia University Research Corporation, with a total funding amount of $348,987, will fund research to investigate how the physical characteristics of metal oxide nanoparticles used as MRI contrast agents impact their interactions with neutrophils and platelets. The central hypothesis is that nanoparticle properties such as metal content, surface coating, and size can modulate neutrophil and platelet nanoparticle transport, activation, aggregate formation, and release of neutrophil extracellular traps, which are important factors for assessing contrast agent safety. The project will utilize static in vitro assays, microfluidic chips, and a mouse model to evaluate these biological responses. In addition, the award includes an education plan to engage underserved K-12 students in West Virginia through hands-on research experiences, interactive STEM outreach, and integrated art and science activities to inspire the next generation of scientists and engineers. The project will run from April 1, 2024 through March 31, 2029.