Project Grant 2338401
- This $327,085 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of new tools and strategies to advance the understanding of lectin proteins and their roles in human health. The key objectives of this 1-year project include: 1) Creating tools to assess how soluble human lectins interact with and influence microbial communities, 2) Developing a...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $135,930 to the University of Connecticut Health Center to investigate the innate immune roles of glycorna - newly discovered biopolymers comprised of small non-coding RNAs and sialic acid-containing N-glycans. The research aims to characterize how the abundance and diversity of glycorna is altered upon...
- The National Institute of General Medical Sciences (NIGMS) awarded a $382,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Texas A&M Engineering Experiment Station (Tees) for the project "Role of Membrane Dynamics in Cell Surface Glycan Recognition" from January 1, 2025 to December 31, 2029. The goal of this project is to investigate how the spatial organization of glycan ligands on cell membranes influences glycobiology processes, and to develop...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $586,230 to The Leland Stanford Junior University to conduct research on the physical organization and molecular transport mechanisms of the cell membrane glycocalyx. The project aims to develop a fundamental biophysical understanding of how the proteins and sugars that make up the protective "shield" on cell surfaces modulate the interactions of proteins, polysaccharides,...
- This $1.8 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Cornell University to develop single molecule tools and techniques for studying coronavirus membrane fusion. The goal is to understand the relationship between coronavirus fusion peptide sequence and target host cell membranes at the nanoscale. Specifically, the awardee will identify and measure the physicochemical interactions between the coronavirus spike...
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- This National Science Foundation Project Grant of $255,927 awarded to Invvax, Inc. on March 1, 2022 seeks to develop stable prophylactic antibodies through February 2023. Funded through the NSF Engineering Directorate's CFDA 47.041 program, this Small Business Innovation Research Phase I project will engineer mutations to antibody Fc regions to resist degradation and enhance binding to the neonatal Fc receptor for potentially decades-long duration. Specifically, the awardee will combine known...
- This $448,150 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) aims to develop a DNA-based toolbox for the rapid and precise modulation of cell membrane protein-protein interactions (PPIs). The goal is to establish a modular approach using antibodies and aptamers to enable targeted DNA barcoding of cell membrane proteins, particularly receptor tyrosine kinases. This will allow for the controlled stabilization of specific PPI pairs on living...
- This National Science Foundation (NSF) Mathematical and Physical Sciences (CFDA 47.049) project grant award of $1,500,000 supports research by Dr. Tamar Schlick of New York University and Dr. Alain Laederach of the University of North Carolina at Chapel Hill. The project aims to develop advanced computational tools to predict and control how viral protein synthesis is affected by programmed ribosomal frameshifting (PRF) - the mechanism by which viruses and human cells modify gene expression. Key...
- This $2 million cooperative agreement from the National Science Foundation will support Protabit LLC in developing artificial intelligence-enabled antibody engineering approaches to generate neutralizing antibodies against SARS-CoV-2. Funded through Jul 2022 to Jun 2024 under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the project aims to discover a large array of high-affinity neutralizing antibodies targeting multiple regions of the SARS-CoV-2 spike protein. This...
CAREER: DECODING THE CODE OF GLYCAN-COLLECTIN INTERACTIONS: COMPUTATIONAL ENGINEERING OF SURFACTANT PROTEINS FOR TAILORED GLYCAN RECOGNITION -CERTAIN VIRUSES AND BACTERIA CAUSE DISEASE (PATHOGENS). PATHOGENS ATTACH SUGARS TO THEIR EXTERIOR TO AVOID DETECTION BY THE IMMUNE SYSTEM. THE IMMUNE SYSTEM PRODUCES PROTEINS (COLLECTINS) THAT RECOGNIZE AND BIND TO FOREIGN SUGARS (GLYCANS). THE OVERALL OBJECTIVES OF THIS PROJECT ARE TO BETTER UNDERSTAND AND IMPROVE THE BINDING OF COLLECTINS TO GLYCANS. THIS COULD DRIVE THE DEVELOPMENT OF IMPROVED VACCINES AND THERAPIES. ARTIFICIAL INTELLIGENCE TOOLS WILL BE EMPLOYED TO HELP DEVELOP DESIGN RULES FOR THE IMPROVED COLLECTINS. ENHANCED BINDING OF THE INFLUENZA A VIRUS WILL BE THE TEST CASE. THE RESULTS OF THE PROJECT WILL ALSO PROVIDE MATERIAL FOR THE BLIND SCIENTIST TOOLKIT THAT THE INVESTIGATOR HAS DEVELOPED THAT TEACHES NON-VISUAL APPROACHES TO SCIENTIFIC EXPLORATION. THE PRIMARY GOALS OF THIS PROJECT ARE TO ELUCIDATE AND OPTIMIZE THE BINDING AFFINITY BETWEEN COLLECTINS, A CLASS OF C-TYPE LECTINS, AND GLYCANS, THE SUGAR STRUCTURES FOUND ON THE SURFACE OF PATHOGENS SUCH AS VIRUSES. THIS RESEARCH AIMS TO ENHANCE THE EARLY DETECTION AND RESPONSE OF THE MAMMALIAN IMMUNE SYSTEM TO VIRAL INFECTIONS. AN INTERDISCIPLINARY APPROACH INTEGRATING COMPUTATIONAL AND EXPERIMENTAL METHODOLOGIES WILL BE UTILIZED. THE STRUCTURAL VARIATIONS AND AMINO ACID SEQUENCES WITHIN THE CARBOHYDRATE RECOGNITION DOMAINS OF SURFACTANT PROTEINS A AND D (SP-D) WILL BE INVESTIGATED. DETAILING THE ANALYSIS OF THE INTERACTIONS AT THE MOLECULAR LEVEL WILL BE USED TO DEVELOP A SET OF RATIONAL DESIGN RULES. THESE RULES WILL GUIDE THE ENGINEERING OF SP-D VARIANTS WITH ENHANCED CAPABILITIES FOR GLYCAN BINDING, PARTICULARLY TAILORED TO TARGET INFLUENZA A STRUCTURES. THE METHODOLOGY INCLUDES COMPREHENSIVE COMPUTATIONAL ANALYSES, MOLECULAR DYNAMICS SIMULATIONS, DOCKING STUDIES, AND IN VITRO BINDING ASSAYS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $173.7k | 9/4/25 | ||
| Not listed | $653.6k | 3/11/24 |