This Project Grant award of $494,829 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at South Dakota State University (SDSU) to elucidate the signaling mechanisms of wall-associated kinase (WAK) immunity receptors in the barley-spot blotch pathosystem. The key objectives are to: 1) determine the physical interaction and subcellular localization of two WAK genes SBS1 and SBS2, 2) elucidate the signaling pathways of these WAK genes, and 3) broaden student awareness and participation in plant pathology research. The research will utilize heterologous protein interaction assays, co-localization studies, and yeast two-hybrid screening to functionally characterize the WAK immunity receptors. The project also incorporates training for undergraduate students and development of outreach workshops to inspire young minds, particularly female students, towards STEM fields. Findings from this award are expected to advance the understanding of plant immune signaling and enable deployment of genetic host resistance in important crops like wheat, corn, and barley. The award period runs from August 1, 2024 to July 31, 2027.
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