This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program provides $242,103 to the Massachusetts Institute of Technology (MIT) to conduct research exploring how proteins and lipids coordinate the formation and function of membrane-associated condensates. The goal is to gain a better understanding of how the cell surface is organized, which could lead to advancements in biotechnology, disease treatment, and our overall understanding of...
This federal Project Grant award of $600,000 from the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049) supports research by Markus Deserno of Carnegie Mellon University to investigate how the asymmetry of cell membranes affects the phase behavior of their lipid constituents. The research aims to develop theoretical and computational techniques to elucidate how factors like differential stress and cholesterol partitioning impact lipid mixing in...
The National Science Foundation awarded a $335,720 project grant to the University of Denver under the Biological Sciences federal grant program (CFDA 47.074) for work beginning August 1, 2021 through July 31, 2024. The grant will support research applying quantitative imaging methods to identify molecular components of multi-vesicular body fusion sites. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research, consistent...
This Project Grant award from the National Science Foundation provides $300,000 to Dr. Michael Phillips at the University of Denver under the Mathematical and Physical Sciences program (CFDA 47.049). The award supports Dr. Phillips' research entitled "MPS-ASCEND: Liquid-Liquid Phase Separation of Heteropolymers: Sequence Details and Coupling to Statistical Fluctuations." Theoretical techniques will be applied to model the behavior of large polymer molecules in solution, with the aim of...
This $274,218.64 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to Brandeis University will support research into the mechanisms underlying exosome release from neurons. The grant aims to determine how exosomes are generated from the endosomal system in neurons and explore neuronal exosome and endosome biology in an animal model. The grantee will manipulate the ESCRT and MUNC13-4/RAB11 pathways to investigate endosomal dynamics...
This $337,863 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research by Professor Ken Marcus and his team at Clemson University to develop new methods for isolating and purifying diverse biological nanoparticles, including exosomes, lentiviruses, and adeno-associated viruses. The researchers aim to characterize and implement a unique fiber-based stationary phase,...
This National Science Foundation (NSF) Project Grant, awarded under the Biological Sciences program (CFDA 47.074), provides $154,000 in funding to Boston University from July 1, 2024 to June 30, 2027 to conduct research on protein aggregation and liquid-liquid phase separation (LLPS). The project, a collaborative effort between US and French researchers, aims to elucidate how protein-rich droplets can promote the pathological aggregation of proteins associated with neurodegenerative diseases,...
The National Science Foundation (NSF) awarded a $1,200,000 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of Washington to conduct research on liquid-liquid phase separation in lipid membranes. The 4-year project aims to: 1) test if asymmetric lipid vesicles phase separate similar to flat membranes; 2) develop new methods to determine lipid ratios in coexisting membrane phases and analyze lipid compositions of vesicles; and 3) use Raman imaging and...
The National Science Foundation (NSF) Division of Chemistry has awarded a 3-year, $450,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of California, San Diego (UCSD) to develop and characterize chemistries for generating dissipative phospholipid vesicles (liposomes) that exist in a non-equilibrium state and are sustained by chemical fuel sources. This work aims to better understand the molecular mechanisms underlying dynamic...
This is a $600,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Davis. The award supports research investigating the fundamental mechanisms underlying liquid-liquid phase separation and membrane remodeling in cell-like environments. The project aims to quantify the dynamics of phase coarsening, map relationships between intravesicular macromolecular crowding and membrane changes, and...