The National Science Foundation (NSF) Division of Mathematical Sciences awarded a $250,000 Project Grant to the University of Pittsburgh to conduct mathematical analyses of multidimensional single cell transcriptional vector fields. The 3-year grant, titled "EMB: Mathematical Analyses of Multidimensional Single Cell Transcriptional Vector Fields," aims to develop data-driven mathematical models describing how genes coordinately regulate the development of different cell types, such as liver cells and neurons. The research will leverage recent advances in single-cell genomics and machine learning to provide mechanistic insights into cell fate transitions, which are critical for understanding disease processes and developing targeted therapies. The project also promotes interdisciplinary collaboration between mathematicians and cell biologists and trains the next generation of researchers in this emerging field.
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