The National Science Foundation (NSF), through its Engineering (ENG) program (CFDA 47.041), has awarded a $219,985 Project Grant to the University of Wisconsin System to conduct research aimed at expanding the substrate range of the microbe Clostridium thermocellum. The key objectives are to: 1) characterize the organism's substrate transport and central metabolism to identify factors limiting its substrate range, 2) identify mutations that allow growth on alternative substrates, and 3) use these alternative substrates to determine limitations on ethanol production. This research seeks to improve the understanding of atypical glycolysis pathways and factors controlling substrate range in cellulolytic organisms, which is essential for advancing metabolic engineering efforts to convert lignocellulosic biomass into fuels and products. In parallel, the project will engage K-12 students in science fairs and summer research experiences. The award period runs from December 15, 2023 to November 30, 2026.
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