Project Grant 2310909

The National Science Foundation (NSF) Office of Advanced Cyberinfrastructure awarded a 4-year, $1,000,899 Project Grant to The Leland Stanford Junior University (Stanford University) under the NSF's Computer and Information Science and Engineering (CISE) program (CFDA 47.070). The project aims to develop and publicly release a novel suite of multifidelity simulation tools for modeling vascular biomechanics and mechanobiology in the open-source SimVascular project. Specifically, the grant will add new capabilities to SimVascular to link blood flow and tissue biomechanics at multiple scales with models of mechanobiology across organ-to-microscale vascular networks. This will enable the research community to study longer-term mechanistic adaptations of the circulatory system, which is critical for assessing long-term outcomes and disease progression. To facilitate adoption, the project will provide accompanying educational and training materials and maintain a sustainable software ecosystem to increase the user community and ensure continued availability and evolution of the enhanced SimVascular platform. No subawards are planned under this grant.