This Project Grant from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation provides $511,901 to Purdue University from September 2021 through July 2025. The award supports research titled "CAREER: REGULATION OF HYALURONAN PRODUCTION AND FUNCTION BY BIOMECHANICAL SIGNALS" under the NSF Engineering Program (CFDA 47.041). The NSF Directorate for Engineering seeks to improve quality of life and economic strength by fostering innovation and...
This $616,151 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The research aims to improve the understanding of how tissues form, how embryos develop, and how diseases progress, with potential implications for advancements in tissue engineering and medicine. The 3-year project, set...
This $265,151 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) aims to develop an integrated computational and experimental approach to determine strategies for modulating lymphatic permeability. The project will use a systems biology approach that iterates between experiments and mathematical modeling to understand how lipids regulate CD36 (a long-chain fatty acid translocase) turnover, lymphatic vessel integrity, and cell signaling. The...
This $646,451 National Science Foundation (NSF) Engineering (CFDA 47.041) faculty early career development (CAREER) grant awarded to the University of Colorado (CU) aims to study how the mechanical properties of the extracellular matrix regulate the function of neutrophils, a key type of innate immune cell. The research objectives are to: 1) decouple the roles of matrix viscoelasticity and stiffness in modulating the neutrophil response, 2) investigate the effect of dynamic tissue stiffening...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research to elucidate how the fluid-like properties of tissue extracellular matrices influence cell fate decisions in response to growth factors. The $480,237 grant, awarded to The Pennsylvania State University (Penn State) on August 1, 2024, will fund the development and characterization of viscoelastic materials to study the impact of matrix viscous dissipation on cell...
This $483,492 Project Grant awarded by the National Science Foundation's Engineering program to the University of Maryland, College Park, aims to develop biomaterial tools for investigating how extracellular matrix (ECM) ligands influence the function of macrophage immune cells. The 5-year project will leverage polyethylene glycol-based biomaterials with known peptide-derived ECM ligands to quantify the impact of ECM ligand-integrin receptor interactions on macrophage activation. The research...
This $314,769 Project Grant award from the National Science Foundation's (NSF) Integrative Activities (CFDA 47.083) program supports research to advance the fundamental understanding of mechanobiological signaling in cells and tissues. The University of Delaware, a private research university, will develop innovative magnetic material platforms that can dynamically control local tissue stiffness to mimic various biological events. Through controlled experiments, the project aims to uncover the...
This Project Grant award from the National Science Foundation (NSF), under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), provides $275,000 to Mellicell Inc. to develop an industrial-scale technology for drug development using mature human fat cells. The broader impact of this SBIR Phase I project is to enable the discovery and development of next-generation therapeutics for obesity and associated medical conditions that can be treated through weight loss. The award will...
This $199,988 National Science Foundation Engineering Research Initiation award will support the development of a 3D in vitro model to study the relationship between changes in brain tissue extracellular matrix composition and neuroinflammation. Specifically, the awardee, Trinity University, will fabricate multi-interpenetrating polymer networks comprised of fibrin, hyaluronic acid, collagen, and polyethylene glycol to mimic key changes in matrix content and study their effect on human astrocyte...
This Project Grant award of $401,889.00 was provided by the National Science Foundation (NSF) through its Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The grant aims to develop a novel mathematical model that integrates experimentally measured intracellular tensions to establish a force architecture throughout migrating cells. This will help identify the key subcellular components and pathways by which external properties direct cell migration, with applications in...