The University of Rochester received a $600,000 Project Grant from the National Science Foundation's (NSF) Division of Computing and Communication Foundations under the Computer and Information Science and Engineering (CFDA 47.070) program. The grant will fund a 3-year effort to identify, characterize, and explore hybrid systems integration of cryogenic electronics crossing multiple temperature boundaries. The primary objective is to determine the optimal placement of functions, technologies, and applications within cryogenic hybrid systems to achieve extreme energy and performance goals. The research aims to develop general design methodologies to support the development of complete systems composed of diverse technologies and applications operating across multiple temperature zones for use in large-scale stationary computing infrastructures like cloud computing and quantum computers.