The National Science Foundation awarded The Pennsylvania State University a $629,976 project grant under the Engineering federal grant program (CFDA 47.041). The grant will support research from April 2023 through March 2026 to enhance cellulase activity through single-molecule imaging and protein engineering.
Specifically, the university will use cutting-edge light microscopy techniques to better understand how cellulases work to break down cellulose, the most abundant biopolymer on earth. By gaining insights into cellulase mechanisms, the researchers aim to design more efficient enzymes that can lower the cost and increase availability of renewable energy from plant-derived cellulose. In parallel, the university will develop and deliver educational materials exposing students to single-molecule biophysics and plant biology. The project also seeks to strengthen the bioeconomy workforce by actively recruiting students from underrepresented populations to participate in the research. Findings from this research could support the development of more effective processes for converting non-food plant materials into renewable biofuels.
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