Project Grant 2247635

Award Date 7/1/23
Completion Date 6/30/26
Dollars Obligated $513K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Vermillion, SD 57069, USA
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The grant funds research aimed at developing next-generation fluorinating reagents that are effective, safe and economical for producing organofluorine compounds of medical and materials interest. Specifically, the university will design and prepare an array of fluorinating reagents with tunable reactivity and selectivity by combining electron-deficient fluoroaromatics and fluoride salts. Researchers will study how varying the degree of electron deficiency affects deoxyfluorination reactions and seek to understand the correlation between key structure-property factors that determine reactivity and selectivity. The grant also supports training students in multifaceted approaches to solving challenging chemistry problems through synthetic, physical organic and computational methods. Results have the potential to provide fundamental knowledge applicable to other research areas involving ionic species.

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