Project Grant 2246856

Under a $579,743 National Science Foundation Project Grant awarded July 1, 2023 through June 30, 2026, the University of California, Los Angeles will provide research services through its Chemistry Department in support of the agency's Mathematical and Physical Sciences program (CFDA 47.049). Specifically, Professor Patrick Harran and colleagues will develop new synthetic tools and methods to create a novel class of fluorinated cyclic peptide compounds, studying their three-dimensional structures and physical properties. They will examine functional group compatibilities, ring size tolerances, and reaction cascades to generate previously unknown heterocyclic ring systems. The outcomes have potential applications across chemical, pharmaceutical and materials industries. The grant also supports training the next generation of scientists. As the prime awardee, UCLA will directly perform the research services. The University's parent organization, the California State Controller's Office, provides financial and administrative oversight as the state entity to which UCLA reports but will not directly conduct grant activities.