This $284,861 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at Purdue University developing new carbonylation methodologies for synthesizing complex chemical structures with medicinal applications. Professor Mingji Dai and his research team are investigating palladium-catalyzed reactions incorporating carbon monoxide to rapidly increase molecular complexity in targeted natural products and related compounds. Specific areas of focus include palladium-catalyzed tandem carbon-carbon bond cleavage and carbonylative lactonization to synthesize fused bicyclic lactones like stemona alkaloids, carbonylative macrolactonization to access complex macrolides, and tandem carbonylative cyclization of natural products featuring electrophilic moieties. In addition to producing new synthetic methodology, Professor Dai's work provides valuable training to postdoctoral researchers, graduate students, and undergraduates. This award is expected to run from August 1, 2022 through April 30, 2024.
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