This National Science Foundation Project Grant of $100,000 supports research into polyelectrolyte multilayered surfaces for use in human mesenchymal stem/stromal cell manufacturing. The goal is to develop a scalable and controllable polymeric coating composed of natural polymers to improve the cell expansion process used in producing therapeutic human mesenchymal stromal cells. The coating is constructed via layer-by-layer assembly of collagen and heparin and has been shown to increase cell viability when cultured on flat surfaces and microcarriers used in suspension-based cultures. When combined with interferon gamma, the coating further enhances the immunosuppressive properties of the cells, yielding a more potent therapeutic product. This technology aims to improve cell behavior, function, and quality in small and large-scale bioreactor systems. If successful, it could lead to more accessible stem cell therapies by improving manufacturing processes. The award falls under the NSF Technology, Innovation, and Partnerships program and supports the agency's mission to advance engineering and technology research.
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