Project Grant 2227063

Award Date 1/1/22
Completion Date 9/30/23
Dollars Obligated $599K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Penn State University, PA 16802, USA
Similar Awards
This National Science Foundation (NSF) Engineering (CFDA 47.041) program grant, in the amount of $400,000, supports the development of a tissue-like, converged sensing platform for tracking excitation-contraction dynamics in cardiac organoids. The project aims to: Develop a scalable assembly strategy to fabricate an array of three-dimensional sensor structures using planar semiconducting graphene material, designed to detect both electrical and mechanical stimuli. Evaluate the multifunctional...
The National Science Foundation awarded a $450,000 Project Grant to the George Washington University under the Engineering federal grant program (CFDA 47.041) to develop scalable heart-on-a-chip platforms. Over a three-year period from April 2022 through March 2025, the University will create automated systems integrating human heart slice culture components with sensor and actuator arrays. This will enable continuous on-chip multiparametric analysis of human cardiac physiology at the cellular...
This $100,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports the development of a 3D human stem cell cardiac model for cardiac electrophysiology medical device safety assessment. Funded under the NSF Engineering program (CFDA 47.041), this award will allow the University of Maryland, College Park to create a novel in vitro model for evaluating the safety and efficacy of cardiac medical devices through January...
This National Science Foundation (NSF) Engineering Program (CFDA 47.041) Project Grant award of $600,000 to Dartmouth College aims to develop methodologies for efficiently manufacturing mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to accelerate drug development and cardiac disease modeling. The project will employ biochip design, machine learning, developmental biology, and tissue engineering approaches to enhance the structural and functional maturity of...
This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
This Project Grant award from the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $199,992 to Boston University to develop a high-throughput electrical stimulation screening platform for assessing the long-term effects of cardiac contractility modulation (CCM) devices on engineered human heart tissue. The project will support a postdoctoral scholar co-mentored by researchers at the Food and Drug Administration (FDA) and Boston University to advance...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) is supporting a collaborative research effort focused on developing an intelligent lab-on-chip device to monitor and promote the maturation of stem cell-derived cardiomyocytes. The $192,150 award to the New York Institute of Technology (NYIT) aims to create an integrated system that can non-invasively evaluate cardiomyocyte maturity in real-time and adaptively apply electrical and mechanical...
This $500,000 Project Grant award, provided by the National Science Foundation's Engineering program (CFDA 47.041), supports the development and validation of automated optoelectronic lab-on-a-chip platforms for comprehensive, real-time, multiparametric monitoring and control of live cell physiology. The research objectives include: 1) Exploring cellular-scale components for crosstalk-free electrical recording, stimulation, and fluorescence monitoring of in vitro live cell function; 2)...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a flexible bioelectronic microarchitecture that integrates a capillary-like delivery network and a tissue-like sensing network to improve cardiac tissue engineering. The $488,026 award supports the creation of a system that can efficiently deliver media and provide real-time physiological feedback to enhance the development of...
This $400,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), under CFDA 47.041 Engineering program, will fund The Johns Hopkins University to develop engineered heart tissue chips for testing nanoparticle-based countermeasures against spaceflight-induced heart disease. The research aims to investigate whether nanoparticles designed to scavenge reactive oxygen species can prevent mitochondrial...

This $599,486 National Science Foundation award under the Engineering (47.041) program will fund the development of an engineered cardiac tissue model with embedded soft microelectronics for continuous cardiotoxicity screening at The Pennsylvania State University from January 2022 to September 2023. The key product is a 3D-bioprinted, microvascularized cardiac tissue model integrated with stretchable microelectronics to enable real-time, intra-tissue measurement of cardiotoxicity responses to pharmaceutical compounds. Researchers will optimize design and fabrication of the engineered tissue model, develop soft, stretchable microelectronics, integrate the microelectronics with the bioprinted cardiac tissue to form a hybrid model, and study drug screening using induced electrophysiological and mechanical beating signals. The hybrid tissue model aims to more accurately predict human responses to drug candidates and reduce costs and animal use in drug development.

Generated 1/7/24, 5:21 AM