This $199,167 Project Grant from the National Science Foundation Division of Environmental Biology will support research to develop a data-driven model of imperfect immunity against COVID-19. The University of Southern California will receive funding to build upon data on COVID-19 reinfections and vaccine breakthroughs to better understand how imperfect protection affects SARS-CoV-2 transmission dynamics and the long-term risks of resurgence. The project directly supports the NSF's Biological Sciences program (CFDA 47.074), which aims to advance biological science knowledge and address major problems facing the nation. Key outcomes will include integrating lessons from relevant coursework into a unified model of immunity against COVID-19 variants over time. This model will be validated using held-out data and incorporated into federal epidemiological modeling hubs to inform COVID-19 projections and policy responses worldwide.
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