This three-year Project Grant from the National Science Foundation's Computer and Information Science and Engineering program, totaling $998,000, will fund research at Augusta University Research Institute to develop a holistic data-driven design framework for modeling and controlling human-cyber-physical systems. Specific products and services include a new hybrid learning architecture to accurately model human behaviors and decision-making; extended reality-assisted interfaces to enhance interaction with semi-autonomous or fully autonomous systems; and a model-based and data-driven control co-design framework to enable adaptable and reliable control in human-in-the-loop scenarios. Validation experiments will utilize human-cyber-physical systems testbeds with extended reality interfaces such as eye-tracking and 3D drone teleoperation. This award supports the program's goals of advancing computing and information sciences research and infrastructure to accelerate discovery and innovation.