This $400,000 National Science Foundation project grant supports computational analysis of synaptic nanodomains at The Salk Institute For Biological Studies from October 2022 through September 2025. Funded through the NSF's STEM Education program (CFDA 47.076), the award aims to build imaging, analytical, and computational tools to investigate the structure of nascent and active zones within synapses. Specifically, the project will create computational tools to automatically delineate nascent zones; apply a new analysis based on information theory to measure synaptic storage capacity; and perform reaction-diffusion simulations to provide a functional estimate for the boundary between nascent and active zones and determine how changes in these zones alter efficacy during synaptic plasticity. Findings will refine understanding of synaptic plasticity mechanisms underlying the advantage of spaced learning. Data sets and AI tools developed will be broadly shared with neuroscientists through the NSF-supported 3DEM portal.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $400.0k | 8/31/22 |