Project Grant 2217494

Award Date 9/1/22
Completion Date 8/31/25
Dollars Obligated $476K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14627, USA
Similar Awards
This National Science Foundation (NSF) award under the Engineering program (CFDA 47.041) provides $624,622 to the University of Vermont & State Agricultural College to study the relationship between the microscopic structure ("microstructure") and macroscopic function of cartilage under various loading conditions. The research project investigates the links between quantitative magnetic resonance imaging (MRI) metrics of cartilage microstructure, experimentally derived cartilage...
This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
This $285,630 Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will support research at the University of New England (UNE) to elucidate the molecular mechanisms of integrin-mediated mechanotransduction in articular chondrocytes. The overarching goal is to advance the understanding of osteoarthritis pathogenesis and explore potential biomechanical or pharmaceutical interventions. The 3-year project will establish baseline catabolic thresholds for...
Drexel University received a $445,522 project grant award from the National Science Foundation to study the biomechanics of the primitive matrix in embryonic cartilage and meniscus. Funded under the NSF's Engineering program (CFDA 47.041), which seeks to improve quality of life and economic strength through engineering research and education, the award runs from May 1, 2021 through April 30, 2024. Under the grant, Drexel University will examine cartilage and meniscus tissue samples from mice...
The University of Rochester received a $736,668 project grant from the National Science Foundation to conduct research on the theory and simulation of laser dressed molecules and materials from June 2021 through May 2024. The grant was awarded under the Mathematical and Physical Sciences program (CFDA 47.049), which aims to strengthen the nation's scientific enterprise through advancing knowledge and understanding of major problems in mathematics and the physical sciences. Through this...
The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded The Johns Hopkins University a $324,511 Project Grant under the Engineering federal grant program (CFDA 47.041) for research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD." The two-year award beginning January 1, 2022 will support research into instabilities and local strains in engineered cartilage scaffolds to better understand...
This National Science Foundation Project Grant of $523,303 supports research at the University of California, Merced from June 2023 through May 2028 under the Engineering program (CFDA 47.041). The award will fund investigation into the role of fibronectin in mediating the adsorption and retention of synovial fluid components to regulate joint boundary lubrication and wear protection. Specifically, the university researchers will develop articular cartilage surface models, quantify synovial...
This three-year, $1.2 million project grant from the National Science Foundation's Engineering program (CFDA 47.041) will support research at Washington State University and Cornell University to develop new tissue engineering strategies for cartilage regeneration. The researchers aim to stimulate adult stem cells to become mature chondrocytes for cartilage production through small molecules that interfere with bone cell differentiation genes. Real-time imaging will monitor cell growth...
The University of Rochester was awarded a $1,829,300.00 Project Grant from the U.S. Department of the Army Medical Command under the Military Medical Research and Development (CFDA 12.420) federal grant program. The grant, with a performance period from August 1, 2024 to July 31, 2027, will support advanced biomedical research focused on "Mechanistic Insight into the Airborne Hazards Exposure-Related Development of Neurological Disorders." As a leading research university, the...

The University of Rochester received a $475,811 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering (47.041) federal grant program. The award will fund research from September 1, 2022 through August 31, 2025 to study how the accumulation of macromolecules influences cartilage mechanics and chondrocyte health. Specifically, the university will analyze how the buildup of large soluble molecules within cartilage pores modifies the tissue's ability to withstand mechanical forces and protect joints. Using computational modeling, analytical modeling, and an ex vivo cartilage model, researchers will test the central hypothesis that absorbing a critical concentration of molecules above a size threshold is detrimental to cartilage health by increasing permeability and altering the time-dependent mechanical response. In addition to advancing scientific understanding of osteoarthritis pathogenesis, the project also includes an educational program providing local high school students with research experience in biomechanics.

Generated 1/6/24, 3:35 PM