This two-year, $211,846 project grant from the National Science Foundation's Division of Materials Research supports research into programmable living materials through synthetic biofilm engineering and quantitative computational modeling at the Massachusetts Institute of Technology. The researchers will develop bioengineering tools to control bacterial cell deposition and assembly into "material blocks" with distinct interfaces. They will also establish modeling approaches to...
The University of Arizona received a $587,130 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering federal grant program (CFDA 47.041). The award will support research from June 2023 to May 2026 exploring the biomechanics and chemotaxis of the pathogenic bacterium Leptospira interrogans. The research will examine how specific bacterial proteins influence physical structure and movement, interaction with...
This $208,784 federal Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research project to study the emergent dynamics and scaling laws of bioinspired lipid membranes. The University of Arizona, as the primary awardee, will integrate experimental methods such as neutron spectroscopy, NMR, and flicker spectroscopy with molecular dynamics simulations. This integrated approach aims to establish the...
The National Science Foundation awarded a $548,102 project grant under the Engineering (47.041) program to the University of Texas at Austin to develop a predictive framework for understanding how bacteria sense and respond to surface mechanics upon attachment. The three-year award beginning April 1, 2022 will support research using atomic force microscopy, high-throughput culturing, finite element modeling, quantitative confocal microscopy, and genetic manipulation to characterize the stresses,...
The National Science Foundation awarded a $996,596 Project Grant to The Regents of the University of Colorado under the Engineering federal grant program (CFDA 47.041) to establish a framework for modeling the mechanical behavior of living building materials for structural applications from August 1, 2022 to July 31, 2027. Specifically, the award will support research to develop a new multiscale cellular and granular material poroelastic formulation for a microbial precipitation-based living...
The National Science Foundation (NSF) awarded a $243,527 Project Grant under its Mathematical and Physical Sciences (CFDA 47.049) program to the University of Massachusetts Boston to study how motile bacteria interact with structured liquid crystal interfaces. The goal is to advance understanding of how these interfaces influence the movement and collective behavior of active microbial materials. The research will leverage micromanufacturing techniques to engineer liquid crystal surfaces and...
The National Science Foundation (NSF) awarded a $187,593 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Arizona, doing business as the Arizona Board of Regents. This 3-year effort, starting on August 1, 2024, seeks to develop novel modeling and simulation approaches for complex material systems. Key objectives include: Utilizing machine learning, mathematical techniques, and physical principles to construct models that provide more realistic...
The National Science Foundation awarded a $934,613 project grant to Princeton University on July 1, 2021, with a completion date of June 30, 2024. The grant supports research under the Biological Sciences program (CFDA 47.074) to study quorum sensing control of bacterial biofilm formation and dispersal. The funding will allow Princeton University researchers to advance scientific understanding of how bacteria communicate to form biofilms and disperse, with the goal of gaining fundamental...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
This $383,799 National Science Foundation project grant supports collaborative research to map protein-membrane interactions across molecular to cellular scales. Funded under the Biological Sciences program (CFDA 47.074), the research aims to better understand how integral membrane proteins and surrounding phospholipid membranes work together to enable cellular processes. The University of Arizona will conduct multiscale modeling from molecular dynamics simulations of single protein-membrane...