North Dakota State University will develop a point-of-care biosensor device for early detection of pancreatic cancer under a $278,820 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (NSF TIP, CFDA 47.084). The university aims to efficiently and accurately detect circulating microRNA biomarkers that have been linked to early pancreatic cancer using an electric field-based, fluorescent disposable sensor. If successful, the sensors could rapidly detect pancreatic cancer biomarkers. The grant will support research into microRNA and DNA hybridization methods, machine learning regression techniques to estimate biomarker concentrations, and automation of microRNA detection for point-of-care applications. The work addresses a critical healthcare need and has potential for commercial impact if an effective early detection solution is developed.
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