Block Grant 2212NMTRPH

Federal Project Grant Award Summary The National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded Columbia University's Health Sciences Division a $902,272 Project Grant effective May 1, 2026, through April 30, 2028, to advance RF-409, a first-in-class synthetic insulin receptor (IR) agonist designed to treat congenital severe insulin resistance syndromes, including Donohue and Rabson-Mendenhall syndromes. These rare, life-threatening disorders caused by insulin...

This federal Formula Grant award, provided by the Federal Highway Administration (FHWA) under the Recreational Trails Program (CFDA 20.219), will fund the construction of a approximately 0.46-mile trail with access ramps, as well as resource surveys and engineering work, for the Memorial Park Conservancy in Texas. The total award amount is $375,000.00, with a performance period starting on June 21, 2024. The primary awardee for this grant is the Texas Department of Transportation (TxDOT),...

Federal Grant Award Summary Rerx Therapeutics, Inc. received a $2.81 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 10, 2025, with completion targeted for June 30, 2027. The project focuses on developing RERX-001, an orally bioavailable small molecule therapeutic designed to address obesity and associated metabolic disorders...

Summary The University of California, San Diego received a $240,000 Project Grant award dated July 14, 2026, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research investigating the parasite proteasome as a novel antimicrobial target for treating cryptosporidiosis, a severe diarrheal disease caused by Cryptosporidium parvum that poses significant threats to children and...

Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $489,500 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective June 5, 2025, through May 31, 2027. The award funds research and development activities focused on translating the compound REPSOX and its analogs toward clinical application as a prophylactic intervention for Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM),...

The Department of Transportation Federal Highway Administration awarded $574,220.12 under the Recreational Trails Program (CFDA 20.219) on September 22, 2022 to the California Department of Transportation for the 2021 Recreational Trails Project: Azalea Hill Trail Development. The project will develop approximately 6,400 linear feet of new multi-use trail, construct a new bridge, retaining wall, causeway, armored rock crossings, and a kiosk in the Mt. Tamalpais Watershed. Additionally, the...

Federal Grant Award Summary The Trustees of Tufts College received a $374,866 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective August 1, 2026, through July 31, 2028. The project develops "Ribo-ATTECs" (ribonucleoprotein autophagy-targeting chimeras), a novel drug modality designed to achieve targeted lysosomal degradation of disease-causing RNA molecules. This research addresses a critical limitation in current...

Federal Grant Award Summary Syntis Bio Inc. received a $694,032 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 17, 2025, with completion targeted for August 31, 2026. The award funds development of SYN-202, a novel oral methionine gamma-lyase (MGL) enzyme therapy designed to treat homocystinuria (HCU), a rare pediatric genetic disorder...

The Department of Transportation Federal Highway Administration awarded a $230,211.87 Formula Grant under the Recreational Trails Program (CFDA 20.219) to the Colorado Department of Transportation on March 28, 2022. The grant funding will support PROJECT TITLE: RT 2022 SNOW GROOMING 6 OF 6, which involves snow grooming services for recreational trails in Colorado. The Recreational Trails Program provides funds to states to develop and maintain recreational trails and trail-related facilities for...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 will provide $463,150 to The Regents of the University of California, San Francisco (UCSF) to establish proof-of-concept for enzyme replacement therapy (ERT) as a lifesaving treatment for sphingosine phosphate lyase insufficiency syndrome (SPLIS), an ultra-rare and often lethal metabolic disorder. The project aims to demonstrate the efficacy of ERT in preserving kidney function and...