Project Grant 2211598
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $980,943 to Purdue University from August 1, 2025 to July 31, 2029. The project aims to develop new artificial intelligence (AI) tools that can automatically interpret cryogenic electron microscopy (cryo-EM) data into accurate 3D molecular structures and validate those structures for errors. The key objectives are: (1) developing deep learning methods to...
- The National Science Foundation (NSF) awarded a $225,000 Project Grant under the Biological Sciences (CFDA 47.074) program to Carnegie Mellon University and Purdue University. The grant, awarded on August 15, 2025, will support the development of a cyberinfrastructure that enables the analysis of cryo-electron tomography (cryo-ET) data. The project aims to build an open-access, annotated database of cryo-ET images and a robust toolbox of computational methods for their analysis. The resulting...
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- Purdue University was awarded a $374,983 Project Grant from the National Science Foundation on May 15, 2021 to support research titled "COLLABORATIVE RESEARCH: FTE: MEDIUM: THREE DIMENSIONAL ALGORITHMIC ASSEMBLY AND INFORMATION STORAGE." The funding will support research from May 15, 2021 through April 30, 2024 under the NSF's Computer and Information Science and Engineering program (CFDA #47.070). This program aims to advance computing, communications, and information science...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $225,000.00 to Carnegie Mellon University and Purdue University to develop a cyberinfrastructure to support the analysis of cryo-electron tomography (cryo-ET) data. The project will build an open-access, annotated database of cryo-ET images, both simulated and experimentally obtained, alongside a toolbox of computational methods for their analysis. This infrastructure will...
- This Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program provides $250,000 to the University of California, Davis to develop fast and robust algorithms for 3D molecular structure reconstruction from cryo-electron microscopy (cryo-EM) data. The project aims to overcome the computational barriers limiting the widespread adoption of cryo-EM by creating new algorithms for image alignment and molecular...
- This three-year Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $164,000 to Purdue University to develop integrated moment-based descriptors and deep neural networks for screening three-dimensional biological data. The researchers will extend mathematical moments to encompass fractional-order moment descriptors, providing a more accurate representation of 3D images. They will integrate the new moment-based approach into a...
- This National Science Foundation project grant of $248,782 awarded on March 15, 2022 will fund the development of computational tools and a database for understanding intrinsically disordered protein-protein and protein-nucleic acid interactions through February 28, 2025. Funded under the Biological Sciences program (CFDA 47.074), Purdue University will create three interlocking computational methods at the 1D, 2D, and 3D levels to advance prediction and modeling of tertiary structures for...
- The National Institutes of Health (NIH) awarded a $1,476,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Trustees of Princeton University for a project titled "Algorithms and Software for Biomolecular Structure Determination at the Proteome Scale". The objective of this 3-year project, starting on September 9, 2025 and ending on August 31, 2028, is to develop novel artificial intelligence (AI) and machine learning (ML) methods to address critical...
- Purdue University received a $495,000 Project Grant award from the National Science Foundation's (NSF) Division of Chemistry and Mathematical and Physical Sciences (CFDA 47.049) program. The grant will fund the development of a new imaging tool based on infrared spectroscopy and molecular chirality to map the chemical composition and translational dynamics within heterogeneous assemblies. Key objectives include enhancing photothermal infrared imaging capabilities in the fingerprinting region,...
Purdue University was awarded a $399,459 project grant from the National Science Foundation's (NSF) Computer and Information Science and Engineering program to develop computational methods for the systematic identification of unknown biomolecular structures from cryo-electron tomography images. Over a three-year period ending in September 2025, the university will create an automated computational pipeline integrating novel techniques for fast subtomogram alignment, shape searching against structural databases, and large-scale identification of macromolecular complexes. The open-source software and algorithms developed under this award will enable cryo-electron tomography to reach its full potential for de novo structural determination and identification of biomolecules at near-atomic resolution in their native cellular contexts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.5k | 8/24/22 |