Project Grant 2154853

Award Date 8/1/22
Completion Date 7/31/25
Dollars Obligated $525K
Federal Grant Program
47.049
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...
This National Science Foundation (NSF) Division of Chemistry Project Grant, under the Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), provides $271,440 to the University of Texas at Dallas to support Professor Filippo Romiti's research on the synthesis of complex heterodimeric bisindole alkaloid natural products. The research aims to develop innovative chemical transformations and synthesis strategies to directly couple monomeric alkaloid units, enabling efficient...
This $575,000 Project Grant award from the National Science Foundation's Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Berkeley will support Professor Thomas Maimone's research on developing new synthetic strategies for constructing complex, nitrogen-containing molecules. The work aims to identify transformations that can efficiently produce unique target molecules with potential applications in pharmaceuticals, agrochemicals, and materials. The...
The National Science Foundation, through its Division of Chemistry and the Mathematical and Physical Sciences program (CFDA 47.049), awarded a $577,690 Project Grant to the University of North Carolina at Chapel Hill from July 1, 2023 through June 30, 2027. The grant supports research to characterize the biosynthetic pathways of dehydroamino acids in nonribosomal peptides, which are biologically and industrially important natural products. The research aims to understand the molecular details of...
This National Science Foundation Division of Chemistry Project Grant of $353,763 awarded on March 1, 2021 through the Mathematical and Physical Sciences program (CFDA 47.049) supports computational studies of hierarchical assemblies in supramolecular comb polymers and discotic mesophases with mixed ligands. The Trustees of the University of Pennsylvania will develop coarse-grained models and carry out systematic computational exploration of the structure and phase behavior of these assemblies....
The National Science Foundation Division of Chemistry awarded a $1,050,000 Project Grant to the Scripps Research Institute under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research exploring attached-ring cross-coupling chemistry and its applications. Over a three-year period from August 1, 2022 to July 31, 2025, Professor Ryan Shenvi of Scripps Research Institute will develop new non-precious metal reagents and methods for concise syntheses of...
David Sarlah of the University of Illinois at Urbana-Champaign will utilize $514,006 in funding from the National Science Foundation's Mathematical and Physical Sciences program to support research in innovative strategies for the complex, total synthesis of naturally occurring molecules from May 1, 2022 to April 30, 2025. Specifically, Sarlah's project will identify novel disconnections and underutilized chemical processes to enable more rapid and controlled preparation of desired molecular...
The Trustees of the University of Pennsylvania were awarded a $500,000 Project Grant from the National Science Foundation Division of Chemistry to support research on oxidation in fragment coupling and fragmentation from August 1, 2021 to July 31, 2024. The grant funds research that aims to promote progress in the mathematical and physical sciences by increasing knowledge and understanding of major problems confronting the nation, as part of NSF's Mathematical and Physical Sciences program (CFDA...
This Project Grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $517,568 to the University of Michigan for research on new strategies for the synthesis of complex, polycyclic molecules of biological importance. Principal Investigator Corinna Schindler will develop approaches relying on hidden symmetry elements and visible light photocatalysis to simplify access to naturally occurring compounds. The...
The federal Project Grant award R35GM156435 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $259,966 grant, awarded on April 21, 2025, supports the development of new synthetic strategies to functionalize pyridine and diazine heterocycles, which are key structural components in many FDA-approved drugs. The research aims to enable medicinal chemists to directly and selectively install a range...

The National Science Foundation Division of Chemistry awarded $525,000 to The Trustees of the University of Pennsylvania through the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support synthetic studies on herquline and lycopodium alkaloids from August 1, 2022 to July 31, 2025.

Under this Project Grant, Professor Dirk Trauner of the University of Pennsylvania will develop new organoboron chemistry methods to synthesize the natural product herquline A, which has shown inhibition of the H1N1 influenza virus but has not been synthesized previously. Trauner's team will also pursue synthetic strategies mimicking biosynthetic pathways to synthesize the lycopodium alkaloids phlegmadine A, huperphlegmines A and B. This work will advance organic chemistry synthesis techniques and further pharmacological research. In addition, Trauner will expand an educational synthetic design platform called Denksport to teach retrosynthetic analysis and a wide range of methods to students.

Generated 1/7/24, 11:58 AM