Project Grant 2147098
- Federal Grant Award Summary Ball State University received a $392,649 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) awarded May 1, 2026, with completion targeted for April 30, 2029. The project develops improved aromatic-metabolizing enzymes through generalizable enzyme engineering strategies, addressing inefficiencies in the synthesis of chemicals, fragrances, and pharmaceuticals containing...
- This three-year, $480,000 Project Grant from the National Science Foundation's Division of Chemistry and Mathematical and Physical Sciences program will support the development of sustainable catalysts and dehydrocoupling chemistry at Arizona State University. Principal Investigator Ryan J. Trovitch will study trends in earth-abundant metal catalysts to synthesize value-added chemicals and polymers more efficiently. Initial work will target precursors for semiconductor manufacturing. The project...
- This Project Grant award from the National Science Foundation (CFDA 47.049 - Mathematical and Physical Sciences) provides $643,347.00 to the University of Alabama-Tuscaloosa to develop computational tools that empower the design of efficient molecular catalysts. The key products and services to be delivered under this 5-year award include: Using high-performance computational screening to identify optimal catalyst structures, compositions, and kinetics to increase activity, selectivity, and...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded $494,253 to Indiana University for a Project Grant (CFDA 47.041 - Engineering) beginning April 15, 2025, with completion targeted for March 31, 2028. The award supports structural and biophysical research on evolved Fe(II)/2-ketoglutarate-dependent azidases designed to expand enzymatic C-H (carbon-hydrogen) functionalization capabilities. The core...
- This $650,000 Project Grant awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) funds an industrial-academic collaboration between Princeton University and the Merck Catalysis Laboratory. The goal is to develop new sustainable catalytic methods for the large-scale synthesis of pharmaceutical drugs using earth-abundant metals like iron, cobalt, and nickel instead of rare precious metals. The research aims to identify viable catalytic...
- This $362,687 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems Engineering program will fund research at the University of Massachusetts Amherst from September 1, 2022 to August 31, 2025. The grant supports the development of new catalytic materials for the deoxydehydration of biomass-derived diols into olefin chemicals. Researchers will gain mechanistic insights into deoxydehydration catalysis and leverage...
- This $303,254 Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), will fund research exploring the idea that the earliest adaptive evolution occurred through self-amplifying cycles of chemical reactions, rather than nucleic acids. Over a three-year period from August 2022 to July 2025, Michigan State University will conduct theoretical and laboratory studies to analyze how mixtures of chemicals could...
- Professor Steven Rokita of Johns Hopkins University was awarded a $510,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to develop new biocatalysts through cofactor engineering. The three-year award running from July 2022 to June 2025 will support research using organic synthesis to create novel cofactors that, paired with protein scaffolds, could enable applications in green chemistry and bioremediation. By modifying cofactors...
- Federal Grant Award Summary Ball State University received a $370,817 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041) effective September 1, 2025, through August 31, 2028. The award funds research and development of heterostructured bismuth-based metal oxide photocatalysts designed to degrade chlorinated organic contaminants, including common groundwater pollutants such...
- This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Emory University to develop practical methods for conducting synthetic organic transformations using low catalyst loadings. The goal is to create highly efficient catalysts, such as rhodium and ruthenium-based catalysts, that can be used in extremely low amounts to enable over 100,000 reaction cycles while...
This three-year Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will support the development of new green-chemical catalysts based on Rieske dioxygenase scaffolds through directed evolution at Ball State University. Totaling $366,434, the award aims to evolve previously uncharacterized dioxygenases found in soil bacteria to expand their substrate ranges for valuable applications in organic synthesis and bioremediation. Specifically, the university will conduct directed molecular evolution to generate Rieske dioxygenases exhibiting expanded reactivity for aromatic compounds and increased activity in the dihydroxylation of alkyl olefins. Following a "design-test-build-learn" cycle, large variant libraries will be produced and screened for enhanced substrate degradation and chemical synthesis abilities. If successful, this work could yield sustainable new catalysts as alternatives to chemical methods for important transformations like asymmetric dihydroxylation, advancing the Engineering program's goals of fostering innovation in engineering research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $366.4k | 3/30/22 |