This $431,542 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems, under the Engineering (47.041) federal grant program, will fund research at Columbia University to define kinase-driven cellular response networks using single-cell genomics techniques. Over a five-year period from February 2022 to January 2027, the university will leverage high-throughput single-cell genomic methods to map the molecular changes cells undergo in response to stress and how those responses depend on individual kinase activity. Information gathered on kinase regulatory networks will be used to manipulate cellular responses to phenotypes of interest, such as treatment-sensitive cell fates. The project also aims to advance equity and inclusion in genomics through educational initiatives like introducing genomics technologies and analysis to local high school students.
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