This $100,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) will support research at the University of Southern California to improve understanding of heart-brain interactions and develop diagnostic monitoring devices. Over a five-year period from April 2022 through March 2027, the grantee will investigate hemodynamic mechanisms through which the heart, aorta and brain dynamically influence one another. Using experimental, computational and machine learning approaches, the researcher aims to elucidate systems-level effects of aortic hemodynamics on the nonlinear relationship between cardiac and cerebral functions. Outcomes seek to facilitate better comprehension of pathophysiological pathways for complex conditions like heart failure, Alzheimer's and dementia. If successful, the long-term goal is creation of affordable heart and brain monitoring technologies to benefit underserved communities.