This $430,660 National Science Foundation project grant funds research at California State University Long Beach from June 2022 to May 2027 to develop vascularized engineered cardiac fibrosis models. The NSF Division of Chemical, Bioengineering, Environmental, and Transport Systems award under the Engineering program (CFDA 47.041) supports investigating vascular repair mechanisms in damaged cardiac fibrotic tissue. The researcher aims to 1) engineer well-defined cardiac fibrosis models replicating remodeling post-myocardial infarction, 2) determine endothelial cell influence on fibrosis progression and the role of fibrosis on vascularization, and 3) investigate designing a vascularized engineered cardiac fibrosis model with flow. Findings intend to further understand fibrosis progression and optimal vascularization approaches, contributing to modulating fibrosis and regeneration balance including angiogenesis. Insights may facilitate advanced regenerative therapies for cardiac regeneration and repair.
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