Biosapien Inc. received a $256,000 Project Grant award from the National Science Foundation on May 1, 2021 to develop a novel 3D printed biodegradable mesh delivering active pharmaceutical ingredients in a sustained and localized manner under the Small Business Innovation Research Phase I program. The SBIR Phase I grant supports the proof-of-concept stage of developing Biosapien's technology, with the work expected to be completed by June 30, 2022. The NSF Technology, Innovation, and...
This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to develop a "living pharmacy" technology for the treatment of diabetes and obesity in cats. The $1,000,000 award, granted to Simmbion LLC (DBA Schapiro Lab 312), will support the demonstration of a novel designer organism that can be administered through a single injection to control blood glucose and weight gain in...
The National Science Foundation (NSF) awarded a $274,966 Project Grant to Remedium Bio Inc., a for-profit organization, under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The grant supports the development of an adjustable gene therapy platform technology that will enable the use of genetic therapeutics beyond rare diseases, tackling large unmet clinical needs such as diabetes, osteoarthritis, and autoimmune diseases. The project aims to develop a dose-adjustable...
This SBIR Direct-to-Phase II federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $1,640,169 to Synvivia, Inc. for the period from December 15, 2024 to November 30, 2026. The funding supports the development and validation of Synvivia's platform for identifying cyclic peptides that can dramatically increase the yield and quality of adeno-associated virus (AAV) vectors...
This Project Grant award of $447,304 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports the development of a compact, chip-scale single-molecule assay (SIMOA) system. The key products and services being delivered include: Implementing a CMOS-embedded microfluidics platform with on-chip sensing pores and electrodes for detecting individual...
This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) provides $275,000 to Ubiquitx Inc., a New York-based small business, to develop a programmable, modular therapeutic platform for the direct modification of proteins of interest (POIs) using artificial intelligence, protein engineering, and mRNA therapeutics. The goal is to expand the applications of the company's Chimeric Ligands for Induced Proximity (CLIPS)...
This Project Grant award of $283,805 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel cell-free, high-throughput platform to expedite the engineering of enzymes for biocatalytic "bioclick" reactions. The project, led by Invizyne Technologies, Inc., a self-certified small disadvantaged business in Monrovia, California, aims to integrate cell-free protein synthesis...
This $963,619 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. The objectives are to: 1) design, simulate, and test 3D channel architectures to manipulate LNP flow conditions and tailor properties; 2)...
This $650,000 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, supports research and development for a next generation probiotics-based platform technology to enable oral delivery of peptide and protein therapeutics. Specifically, the project aims to (1) develop an antibiotic-resistance-free expression system for stable, high-level production of therapeutic peptides in Lactobacillus probiotic strains, (2) create inducible...
Neyroblastgx LLC was awarded a $255,997 Project Grant from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program. The grant will support the company's research efforts to genetically engineer dendritic cells to activate T cells specific to the SARS-CoV-2 spike protein, with the goal of developing a novel approach to treating COVID-19. The research is expected to be conducted between April 2021 and December 2022. The NSF Technology, Innovation, and...