Project Grant 2105598

This three-year project grant from the National Science Foundation Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), provides $462,000 to Virginia Polytechnic Institute and State University from July 2021 through June 2024. The grant supports mechanistic investigation of radical SAM methylases involved in tetrahydromethanopterin biosynthesis. A sub-award of $100,000 is also provided to Auburn University to support related research into the mechanistic investigation of these radical SAM methylases. The funding advances the program's goals of increasing fundamental scientific knowledge and understanding of major problems in the mathematical and physical sciences through mechanistic study of these important enzyme classes involved in carbon metabolism.