Baylor University received a $1.1 million Project Grant award from the National Science Foundation under the Biological Sciences program (CFDA 47.074) for the period of March 1, 2022 through February 28, 2027. The award will support research into investigations of dynamic DNA recognition and processing during eukaryotic nucleotide excision repair. The research aims to obtain detailed molecular and structural understanding of critical steps in the initiation of nucleotide excision repair...
Baylor University will receive $805,201 over four years from the National Science Foundation under the Biological Sciences federal grant program (CFDA 47.074) to study the decoupling of DNA unwinding and synthesis in the replisome and induce genome instability. This Project Grant award, made on June 1, 2021, will fund research examining how the replication machinery unwinds and copies DNA, with the goal of increasing understanding of major biological problems as described in the program...
Baylor University will receive $440,000 from the National Science Foundation under the Mathematical and Physical Sciences program (CFDA 47.049) to investigate new methods for measuring and manipulating the electrostatic properties of proteins through September 1, 2022 to August 31, 2025. Professor Bryan F. Shaw and his research team will use capillary electrophoresis to evaluate how the net charges of various proteins change during protein crowding and electron transfer processes. The team...
Baylor University received a $162,045 Project Grant award from the National Science Foundation Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049) for the period of February 1, 2022 through September 30, 2022. The grant funds research into discovering new metal-based compounds and linking their chemical structures to magnetic, electrical, and thermal properties for energy applications. Specifically, the principal investigator will grow large single...
The National Science Foundation awarded Northwestern University a $525,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to develop protein crystallization programmed with DNA. This three-year award beginning June 1, 2021 will support research to promote progress in the mathematical and physical sciences by increasing understanding of major problems through the development of new techniques to crystallize proteins using DNA programming. The University will...
Baylor College of Medicine will use a $300,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) to research reversing the amino acid sequences of proteins. The researchers will use machine learning algorithms to identify amino acids that prevent proper folding of reverse proteins and experimentally test computational predictions to improve folding and function. In parallel, they will apply directed evolution to improve the functions of...
This three-year, $353,871 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems, under the Engineering program (CFDA 47.041), will fund research at Baylor University to develop molecular assemblies directed by halogen bonding and other noncovalent interactions. The university will characterize molecular properties of halogen bond donors and acceptors, assess stability and bond strengths, and direct the assembly of two- and...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049), in the amount of $642,000, will fund research at Northwestern University to develop novel hybrid protein-DNA supramolecular structures. The key objectives are to: (1) design generalizable strategies for site-specific DNA functionalization to control proteins in 1D arrays; (2) create dynamic, DNA-driven 2D protein lattices; and (3) utilize DNA interactions to facilitate...
This three-year $1,198,460 Project Grant from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports the development of deep learning models for protein-DNA complex structure prediction, design, and evaluation. Professors David Baker and Frank DiMaio of the University of Washington Department of Biochemistry, along with Barry Stoddard of the Fred Hutchinson Cancer Center, will create three deep learning models: one for predicting protein-DNA...
Baylor University was awarded a $177,327 project grant from the National Science Foundation Division of Astronomical Sciences on September 1, 2021, with a completion date of August 31, 2024. The grant falls under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), which aims to promote progress in these fields and strengthen the nation's scientific enterprise. Under this award, Baylor University will conduct collaborative research exploring the Milky Way galaxy and its white...