Formula Grant P425F200675

The National Academy of Sciences was awarded a $199,912.00 Project Grant by the Department of the Navy Secretary of the Navy Office of Naval Research on August 1, 2023 under the Basic and Applied Scientific Research federal grant program (CFDA 12.300). The purpose of this one-year grant is to convene a workshop to identify emerging science and technology that can address naval undersea medicine needs. The National Academy of Sciences has extensive experience providing expert convening,...

This Project Grant award of $804,690 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program aims to determine the relationship between N-acetyl-aspartyl-glutamate (NAAG) levels and memory deficits in schizophrenia patients in mid- to late-life. The funded research will measure NAAG levels using magnetic resonance spectroscopy and correlate them with declarative and working memory performance, as well as neural activity during memory...

This Project Grant award from the National Science Foundation (NSF) Division of Chemistry aims to develop a new class of rechargeable battery that pairs sodium metal with nitrogen oxide (NOx) gases. The $300,000 award made under the NSF's Mathematical and Physical Sciences (CFDA 47.049) program supports research at The Ohio State University to establish the fundamental (electro)chemistry of these Na-NOx batteries, improve their stability, and design flow cell prototypes. Key objectives include...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,434,495 to Neuronasal Inc. to develop a novel intranasal (IN) nose-to-brain (N2B) treatment option for Parkinson's disease (PD) using the antioxidant N-acetylcysteine (NAC). The primary objectives are to: 1) establish the regional and temporal bioavailability profile of 50 mg/kg IV NAC in PD patients, 2) compare the bioavailability and safety of 200 mg and 400 mg IN N2B NAC versus the IV...

Novelmed Therapeutics, Inc. was awarded a $900,000 Project Grant from the National Institutes of Health's National Institute on Aging to develop a selective inhibitor of the alternative pathway of complement as a treatment for Neuromyelitis Optica Spectrum Disorder. Under the grant, Novelmed will conduct preclinical studies to evaluate its lead drug candidate NM5072, including in vitro and ex vivo assays to confirm the drug's mechanism of action and selective inhibition of the alternative...

The National Institute on Aging (NIA) awarded a $295,000 Project Grant (CFDA 93.866 - Aging Research) to Florida International University to develop biotherapeutic nanogels for the treatment of Alzheimer's disease. The goal is to create a novel nanogel system that can effectively cross the blood-brain barrier, inhibit amyloid-beta aggregation, and reduce oxidative stress and neuroinflammation associated with Alzheimer's. The project will focus on improving the nanogel formulation for enhanced...

The National Institute on Aging (NIA) awarded a $949,062 Project Grant (CFDA 93.866) to Somatoceutics LLC to develop a non-toxic, peptide-based nanomaterial (SMC-101 nanotubes) for delivering drugs across the blood-brain barrier to treat Alzheimer's disease and other dementias. The objectives are to optimize the nanotubes for drug-loading and transcytosis across a blood-brain barrier model in vitro, and then evaluate their toxicity and ability to deliver the drug galantamine to the central...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $294,452 to New York University School of Medicine to investigate the role of the sodium-potassium ATPase (ATP1B3 subunit) in regulating T cell function and its potential as a drug target for autoimmune diseases. The research aims to determine how ATP1B3 controls the sodium-potassium ATPase in T cells, the signaling...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute. The purpose of this 2-year grant, with a start date of January 23, 2025, is to evaluate recently discovered neuraminidase broadly neutralizing antibodies (NA BnAbs) for their potential use in a universal influenza vaccine. The research will assess factors such as precursor frequency,...

This National Science Foundation Project Grant of $994,034 supports the development of novel computational algorithms and multiscale simulations to study the ion transport mechanism of the nitrate/nitrite transporter protein Nark. Funded under the Mathematical and Physical Sciences program (CFDA 47.049), principal investigators Hai Lin and Emilie Guidez of the University of Colorado Denver will formulate new adaptive multi-layer simulation methods combining quantum and classical modeling...