Formula Grant 1901NVOANS

This federal Project Grant award of $429,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Oregon Health & Science University (OHSU) to investigate the converging molecular mechanisms between axon degeneration and astrocyte morphogenesis. The primary objectives are to leverage the larval zebrafish system to determine if the roles of...

Siteone Therapeutics, Inc. was awarded a $4,363,269 Project Grant from the National Eye Institute of the National Institutes of Health to develop a topical ocular analgesic product for the treatment of ocular pain. The grant falls under the Vision Research program (CFDA 93.867), which supports research to address leading causes of blindness and impaired vision. Through the two-year project period ending August 2023, Siteone will complete GLP nonclinical safety studies, drug product...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $242,310.00 to Oregon Health & Science University to conduct research on the role of P/Q-type calcium channels in the development of oligodendrocyte lineage cells (OLCs), which are responsible for myelin production in the central nervous system. The key objectives are to:...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $291,020 to the University of Colorado-Denver to investigate the role of Wnt signaling effectors in regulating the neuron-glia switch and oligodendrocyte progenitor cell (OPC) specification during nervous system development and after injury. The research aims to use...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Diego provides $772,581 to investigate the role of the transcription factor SOX18 in neurovascular dysfunction associated with Alzheimer's disease. The research aims to examine how downregulation of SOX18 in brain endothelial cells impacts angiogenesis, blood-brain barrier formation, and the progression of Alzheimer's disease pathology. The project will use mouse...

This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $459,000.00 in funding to Iowa State University of Science and Technology to investigate the mechanisms of neurodegeneration induced by organophosphate nerve agents (OPNAs). The research aims to characterize the interactions between the kinases Fyn, Tau, and CDK5, as well as their impacts on neuronal hyperexcitability, neuroinflammation, and...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $162,728 to the University of California, San Diego (UCSD) to conduct a mechanistic study on cardiovascular outcomes in patients with comorbid obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), referred to as overlap syndrome (OVS). The key objectives are to evaluate the underlying mechanisms behind...

The federal Project Grant award of $429,000 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of Schwann cell Piezo1 in pain sensation. The key products and services to be delivered through this 2-year award include: Developing and producing adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell Piezo1 expression...

This Project Grant award, funded by the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), supports research to develop new diagnostic testing methods for open radio access network (O-RAN) subsystems in 5G networks and beyond. The $200,000 award to the University of California, Los Angeles (UCLA) aims to (1) achieve near-complete test coverage by identifying dependencies between RAN software procedures and interfaces, (2)...

The National Eye Institute (NEI) awarded a $245,243 Project Grant (CFDA 93.867 - Vision Research) to Duke University to develop and validate a novel method for measuring ocular pulse amplitude (OPA) using fixed force applanation tonometry. The project aims to: 1) validate the applanation-based OPA measurement technique on non-human primates implanted with an intraocular pressure telemetry system in normotensive and hypertensive eyes, and 2) assess the repeatability and reproducibility of the OPA...