This Cooperative Agreement award, funded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) for $310,185, aims to analytically and clinically validate a DNA methylation assay to predict recurrence in patients with stage II melanoma. The key products and services to be delivered under this 2-year award include: 1) establishing the technical sensitivity and reproducibility of the methylation assay, 2) examining the potential interference from melanocytic nevi, 3) conducting inter-laboratory harmonization studies, 4) analyzing tumor samples from a prospective cohort of stage II melanoma patients to refine the recurrence prediction model, and 5) validating the model in a separate patient group. The goal is to develop a recurrence prediction tool that combines clinicopathological factors with a set of differentially methylated DNA loci to more accurately classify high- and low-risk patients than using clinicopathological factors alone. This work will leverage the Infinium MethylationEPIC Beadchip v2.0 array, which is already in use in clinical laboratories, to facilitate rapid testing in other patient cohorts and potential clinical utility trials.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $310.2k | 4/2/25 |