This federal Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $257,709 to the University of California, Los Angeles (UCLA) to investigate the impact of dietary lipids on the initiation and progression of pancreatic ductal adenocarcinoma (PDA). The research project has two main aims: 1) Examine the effects of a high-fat diet comprised of lard (HFLD), which contains mostly saturated long-chain fatty acids, on PDA tumorigenesis using...
This Project Grant award from the National Cancer Institute (NCI), under the Cancer Research Manpower (CFDA 93.398) program, supports research to investigate the role of adipose tissue (fat) in facilitating tumor growth and cancer cachexia (wasting syndrome) in lung cancer. The $129,624 award to the University of Vermont & State Agricultural College aims to employ pharmacological interventions, a novel mouse model, and in vitro studies to understand how fat substrates, both endogenous and...
This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $639,882 to the University of North Carolina at Chapel Hill to conduct research aimed at elucidating the molecular mechanisms underlying metastasis organ tropism in breast cancer. The project will utilize a comprehensive dataset of human primary and metastatic tumor samples, as well as genetically engineered mouse models, to identify the molecular determinants driving lung and...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $472,921 to the University of Utah to investigate the role of the CR1 protein pathway in regulating cellular plasticity and heterogeneity in breast cancer progression. The 5-year research project aims to elucidate the molecular mechanisms by which CR1 coordinates the reprogramming of cancer cells and their neighboring cells under stress conditions, with the goal of identifying new...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $433,157 to the Northshore University Healthsystem Research Institute to investigate the role of lipid-rich macrophages in the tumor microenvironment of prostate cancer. The primary objectives are to define the mechanisms regulating the immuno-metabolic axis in adipose tissue macrophages and tumor-associated macrophages, and determine whether a metabolically-activated macrophage...
This federal Project Grant award from the National Cancer Institute (CFDA Program 93.393 - Cancer Cause and Prevention Research) to Northwestern University totals $187,000.00 and is effective from March 10, 2025 to February 28, 2027. The project aims to investigate how altered lipid metabolism and metabolic flux can lead to epigenetic reprogramming and expression of neural genes in breast epithelial cells, which may contribute to the development of estrogen receptor-negative breast cancer. Key...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $564,695 to The University of Texas MD Anderson Cancer Center to study a new driver and therapeutic vulnerability of bone metastasis in breast cancer. The research aims to explore the role of the protein acyl-CoA binding protein (ACBP) in promoting bone metastasis through regulating lipid metabolism and protecting cancer cells from ferroptosis. The 5-year project, starting on June 10,...
The National Cancer Institute (NCI) awarded a $2,489,032 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Sloan-Kettering Institute for Cancer Research. The 5-year award, effective August 1, 2025, will support three highly integrated research projects focused on determining the roles, regulation, and underlying mechanisms of lipid metabolism in ferroptosis, a form of iron-dependent cell death, and exploring novel cancer therapeutic approaches based on these...
This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $441,913 to Tufts University School of Medicine to leverage existing DNA methylation data to better understand the biological pathways linking obesity and increased risk of 13 obesity-related cancers. The research aims to identify specific adiposity-related DNA methylation markers associated with these obesity-related cancers, explore their underlying gene ontology, and...
This Project Grant award of $147,486 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) supports research at the University of Pittsburgh to investigate the role of altered lipid metabolism in CD8 T cell exhaustion within the tumor microenvironment. The project aims to (1) evaluate the impact of abolishing citrate transport on carbon utilization and effector function of CD8 T cells in the tumor environment, and (2) determine the role of stored lipids in CD8 T cell...