Cooperative Agreement UG3AG097155
- The National Institute on Aging (NIA) awarded a $2,552,654.85 project grant to Vanderbilt University Medical Center under the Aging Research federal grant program (CFDA 93.866) on January 1, 2025. This grant supports efforts to systematically screen and validate drug repurposing candidates for Alzheimer's disease and related dementias (AD/ADRD). The project aims to integrate genetics, transcriptomics, literature, and clinical data with advanced informatic technologies and computational...
- The National Institute on Aging (NIA) awarded a $350,001 Project Grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) to unravel the role of clonal hematopoiesis (CH) in neurodegenerative diseases. The project will leverage genomic and functional data to investigate the associations between different CH types, including clonal hematopoiesis of indeterminate potential (CHIP), autosomal mosaic chromosomal alteration (MCA), and loss of the Y chromosome...
- This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...
- This UG3/UH3 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $900,195 to The Leland Stanford Junior University to discover and validate novel antifibrotic compounds for treating cardiac fibrosis in aging populations. The project leverages cutting-edge technologies including human induced pluripotent stem cells, artificial intelligence, and advanced preclinical models. In the UG3 phase, the project will conduct high-throughput screening of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides funding of $158,544 to Vanderbilt University Medical Center (VUMC) from August 1, 2025 to July 31, 2030. The project aims to advance the understanding of clonal hematopoiesis of indeterminate potential (CHIP) and its role in the development of atherosclerotic cardiovascular disease (ASCVD). Specifically, the grant will (1) identify...
- This $1,044,855 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund Nemalife Inc. to deliver high-throughput testing of anti-aging and FDA-approved drugs in genetically diverse invertebrate Alzheimer's disease models. Under the Aging Research program (CFDA 93.866), the awardee will screen 300 anti-aging compounds and 200 FDA drugs to identify candidates that improve neuronal aging and protect against protein misfolding diseases...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,705 Project Grant under the Aging Research program (CFDA 93.866) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The award aims to conduct research on "Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis During Aging," with a project period from June 15, 2025 to May 31, 2027. The research will use single-cell...
- This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,815,841 to the University of Alabama at Birmingham (UAB) to conduct research using cerebral and cardiac organoids derived from human induced pluripotent stem cells. The goal is to study how the low Earth orbit environment, including microgravity and ionizing radiation, can accelerate aging processes and their effects on the development and progression of Alzheimer's disease. The...
This $1,013,072 Cooperative Agreement award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a two-phase project by Vanderbilt University Medical Center (VUMC) to identify and repurpose existing medications or investigational therapeutics to address clonal hematopoiesis of indeterminate potential (CHIP), a fundamental mechanism of aging. In the initial UG3 phase, VUMC will utilize single cell machine learning foundation models, human genetics, and electronic health records to virtually screen for potential drugs to reverse CHIP pathology. The UH3 phase will then experimentally validate the most promising drug candidates in in vitro and in vivo CHIP models. Successful completion of this project aims to rapidly translate these findings into the clinic by repurposing FDA-approved medications to mitigate CHIP and associated aging-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/29/25 |