Cooperative Agreement U24CA302705
- This $5,041,790 cooperative agreement award from the National Cancer Institute (NCI), under the Cancer Centers Support Grants program (CFDA 93.397), will fund research projects at the University of California, San Francisco (UCSF) to improve cancer health disparities. The key products and services to be delivered include: Three translational cancer health disparities research projects focused on meningioma, prostate cancer, and breast cancer. The projects aim to evaluate the interplay of...
- The University of California, Irvine (UCI) was awarded a $2,186,372 Project Grant under the National Cancer Institute's (NCI) Cancer Biology Research program (CFDA 93.396). The 5-year grant, which began on April 1, 2025, will support a research program focused on understanding the fundamental biological mechanisms of cancer initiation and progression. The program includes three interdisciplinary research projects that will leverage mouse models to investigate the role of stochastic,...
- The Cooperative Agreement award titled "CHARACTERIZING GENETIC RISK OF CANCER ACROSS DIVERSE POPULATIONS THROUGH MULTI-ANCESTRY EPIGENOME PROFILING AND CHROMATIN QTL DISCOVERY" is funded by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393). The $720,252 award to the Dana-Farber Cancer Institute aims to identify genetic variants that influence cancer risk regulation across diverse ancestral populations. The project will profile gene...
- The University of California, San Diego (UCSD) was awarded a $444,952 Project Grant by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to conduct research exploring the impact of base deaminase deregulation on precancer evolution. The 5-year grant, which commenced on December 1, 2024, aims to elucidate the relative roles of APOBEC3C and ADAR1 deaminases in driving the progression of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML). The research...
- This Cooperative Agreement awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $1,281,520.00 in funding to The Leland Stanford Junior University to conduct research on the fundamental biological mechanisms of cancer metastasis, organ tropism, and immune evasion. The project aims to integrate genetic barcoding with single-cell profiling to uncover the key molecular drivers underlying metastatic fitness and diverse cancer cell states in pancreatic ductal...
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $1,583,640 to the University of California, San Diego (UC San Diego) from June 23, 2025 to May 31, 2028 to advance spatial metabolomics research for cancer. The project aims to develop and apply the METASPACE open-source software platform to enable data analysis and interpretation of large, complex spatial metabolomics datasets generated through imaging mass spectrometry techniques....
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $809,106 to The Washington University from September 1, 2025 through August 31, 2030 to accelerate the expert crowdsourcing of cancer variant interpretation through the CIVIC (Clinical Interpretations of Variants in Cancer) web resource. CIVIC is a community-driven platform that centralizes and standardizes expert-curated interpretations of cancer-related genetic...
- This federal Project Grant award of $680,598 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research to understand the role of the Cullin-5 complex in regulating T cell dysfunction in cancer. The research aims to develop new therapeutic approaches to engineer T cells with durable effector function, by targeting the Cullin-5 complex to prevent T cell dysfunction caused by chronic tumor antigen stimulation. The award was provided to the...
- The University of Southern California (USC) received a $704,882 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) to define the genetic factors underlying familial prostate cancer in African American (AA) men. The project aims to develop improved risk prediction models that incorporate polygenic risk scores, pathogenic variants, and family history of prostate cancer for the AA population. By leveraging existing...
- The National Cancer Institute awarded a 5-year, $667,379 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to the University of California, Irvine (UCI) on February 1, 2025. The grant supports research to decode the role of polyadenylation, a critical mRNA processing step, in health and disease. Key activities include computational modeling to predict the impact of genetic variants on mRNA stability and processing, as well as high-throughput experiments to quantify how...
The University of California, Santa Cruz received a $660,079 Cooperative Agreement award from the National Cancer Institute's (CFDA 93.393) Cancer Cause and Prevention Research program, effective September 1, 2025 through August 31, 2030. The purpose of the award is to maintain and expand the BRCA Exchange, the world's largest public database of genetic variants associated with hereditary breast, ovarian, pancreatic, and prostate cancers. The project will refactor the database infrastructure to promote expansion and leverage emerging variant annotation standards, as well as leverage new data sources to enhance the knowledge base. This resource is widely utilized by over 3,000 users per month globally, with the data incorporated into major cancer research platforms. The award supports this critical effort to reduce the burden of hereditary cancers by improving the classification and sharing of genetic variants.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $660.1k | 8/19/25 |