Cooperative Agreement U01FD008652
- This Cooperative Agreement award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) provides $1,498,464 to Kaiser Foundation Hospitals to develop and validate AI-enabled echocardiographic biomarkers and integrate real-world electronic health record data to improve early detection and risk stratification of cancer therapy-related cardiac dysfunction (CTRCD). The project aims to transform cardio-oncology care by leveraging a diverse cohort of over 34,000 patients treated...
- This $1,499,996 Cooperative Agreement awarded by the Food and Drug Administration (FDA) under the FDA Research program (CFDA 93.103) will support research at the University of Texas MD Anderson Cancer Center in Houston, TX. The project aims to investigate metabolomic and genetic factors that may decouple the anti-tumor efficacy and cardiovascular toxicity associated with immune checkpoint inhibitor (ICI) cancer treatments. Specifically, the research will examine the role of immune cell...
- This Cooperative Agreement was awarded by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), to the University of North Carolina at Chapel Hill. The $1,905,986 award, which began on July 30, 2025 and is scheduled to conclude on June 30, 2032, will fund a prospective randomized trial to determine optimal strategies for screening, identifying, and treating subclinical coronary atherosclerosis in young and middle-aged adults. The...
- This federal Project Grant award, valued at $392,037, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to New York University School of Medicine. The project aims to conduct site surveys and design questionnaires to support the future development of an international, multisite randomized clinical trial. The trial will evaluate the use of perioperative biomarker-based precision care, including targeted long-term use of...
- This $399,998 Cooperative Agreement award from the National Institute of Standards and Technology (NIST) under the Science, Technology, Business and/or Education Outreach program (CFDA 11.620) aims to develop a commercial prototype of a quantitative computed tomography (CT)/magnetic resonance imaging (MRI) fat phantom. The phantom is necessary for quality assurance and harmonization of CT and MRI metrics of liver and muscle fat, enabling opportunistic screening for metabolic...
- This $304,119 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of innovative in vitro 3D atherosclerosis models and high-throughput drug screening assays by Endomimetics LLC. The key objectives are to create an automated, precise approach for fabricating advanced 3D vascular sheet and atherosclerosis models, which will enable efficient, high-throughput testing of drug...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $617,366 to the University of California, Irvine to develop an integrated intravascular imaging system incorporating optical coherence tomography (OCT), ultrasound (US), and photoacoustic tomography (PAT) technologies. The objective is to create a single, multimodal imaging probe that can provide detailed morphology and functional information on...
- This $739,466 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop a comprehensive PET attenuation correction scheme for cardiac PET/MR imaging. The key products and services to be delivered include: Fabricating a device to rapidly position and remove an external PET source in a PET/MR system for practical and safe patient imaging. Developing algorithms for real-time hardware optimization and deep learning...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $413,595 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Unandup, LLC, a St. Louis-based technology development firm, to fund the development of a Magnetic Rotational Platform for Coronary Lesions. The project aims to address the significant clinical challenges associated with percutaneous coronary intervention (PCI) procedures, particularly in navigating tortuous vessels and enabling stent...
- This $388,673 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) supports the development of novel statistical methods to identify and evaluate predictive biomarkers for targeted cancer therapies using data from non-randomized Phase II clinical trials. The key products of this 2-year project, led by the University of Kentucky Research Foundation, include: Novel semiparametric statistical models to identify and...
This $249,580 Cooperative Agreement award from the Food and Drug Administration (FDA) Research program (CFDA 93.103) supports a project by the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center to conduct analytic validation studies for using non-calcified plaque volume (NCPV) as an enrichment biomarker in coronary artery disease clinical trials. The goal is to standardize the precision, repeatability, and accuracy of NCTA-derived NCPV measurements to support qualification of this biomarker with the FDA. This will involve comparative studies using different software packages to assess the impact of measurement tools. These validation studies are critical for submitting an FDA qualification plan to establish NCPV as a prognostic marker to optimize risk assessment of participants in cardiovascular disease clinical trials.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.6k | 9/10/25 |