Cooperative Agreement U01EB036955
- This federal Project Grant award of $425,226 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to establish the feasibility of engineering "trained innate immunity" using biomaterial implants. The primary objectives are to investigate the effects of scaffold pore size and degradation on innate immune response, as well as determine the aspects of the foreign body response necessary for innate immune training. The...
- The University of Michigan received a $1,714,839 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The objective of this proof-of-concept study is to develop bispecific antibodies (Babs) fused to IL-2, referred to as IL-2 immunocytokines, that can be delivered non-invasively via intravenous administration, efficiently cross the...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $359,995 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to Clemson University. The funding supports the development and validation of a novel X-ray visualized immunosensor (X-VIS) that can be attached to implanted medical devices to detect and monitor local infection biomarkers. The project aims to fabricate a...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $222,708 Project Grant to The Trustees of Columbia University in the City of New York under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant, which runs from May 1, 2025 to December 31, 2028, will support research to develop self-assembling modular hydrogels that can programmably display glycan ligands to direct immune cell phenotypes. This...
- This $1,302,368 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will establish a National Center for Biomedical Imaging and Bioengineering at the University of Michigan. The center will leverage microsystems technology to develop miniature scanning, actuation, and sensing devices for use in fiber-coupled microendoscopes....
- This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,108,154 to develop a stem cell-based multi-cellular platform that integrates diverse types of immune cells with stem cell-derived islets. The goal is to create an improved preclinical research model to accelerate the development of therapeutic interventions for Type 1...
- This federal Project Grant award, valued at $231,934.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of a new modular platform technology that mimics lymph nodes to improve the engineering of T cells for cellular immunotherapy. The funded research aims to create biomimetic scaffolds that can...
- This $616,897 Project Grant was awarded on August 8, 2025 by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of synthetic compartments that can insulate and sequester signaling components to rewire inflammatory signaling and restore immune cell function. Key objectives include insulating and shutting down components of...
- This Project Grant award of $348,373 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a novel family of biosensors that can be used to report on and dynamically regulate changes in neuroinflammation within the brains of live animals. The key products and services to be delivered through this grant include: 1) Developing and...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $300,000 Project Grant to Electronic Biosciences, Inc. to develop a novel point-of-care technology for monitoring immunosuppressant drug levels. The key product being developed is a portable, fingerstick-based testing system that can provide convenient and frequent immunosuppressant drug level measurements. This will enable more precise dosing for...
This Cooperative Agreement award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $536,496.00 to the Regents of the University of Michigan to develop an injectable scaffold system for early detection of immune dysregulation and monitoring response to immunotherapies. The project aims to create a "living sentinel" that can monitor immune system changes to identify disease at early stages, using type 1 diabetes mellitus as a model system. The research seeks to advance technologies for prevention, detection, diagnosis, and treatment of chronic diseases where undesired immune responses are central to disease progression or limit therapeutic efficacy. The award period runs from August 8, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $536.5k | 8/6/25 |