Cooperative Agreement U01CA289839
Award Date
8/1/25
Completion Date
7/31/30
Dollars Obligated
$640K
Federal Agency
National Cancer Institute
Federal Grant Program
93.396
Assistance Type
Cooperative Agreement
Place of Performance
North Carolina, USA
Similar Awards
This $369,868 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to investigate the functional role of mitochondrial transfer from nerves to breast cancer cells, and how this process impacts cancer metastasis and the generation of cancer stem cells. The project aims to use innovative lineage-tracing techniques to quantify the contribution of nerve-to-cancer mitochondrial transfer to the breast cancer metastasis cascade, and evaluate...
This Cooperative Agreement award from the National Cancer Institute, a division of the Department of Health and Human Services, provides $380,509 under the Cancer Biology Research program to The Trustees of Columbia University in New York. The award supports research to elucidate the molecular drivers of melanoma liver metastasis and associated resistance to immunotherapies. Specifically, the researchers will characterize a novel preclinical mouse model that recapitulates genomic and...
This $544,475 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop an in vitro cancer metastasis model system using decellularized organ-specific tissue (biomatrices) to study organ-specific cancer metastasis. The University of Texas Southwestern Medical Center, the awardee, hypothesizes that the biomatrices can recapitulate the organ microenvironment and enable the growth of organ-specific tumor colonies, which can be used to investigate...
The National Cancer Institute (NCI) awarded a $791,820 Cooperative Agreement under CFDA 93.396 - Cancer Biology Research to the University of California, San Diego (UCSD) to advance the METASPACE open-source software platform for spatial metabolomics in cancer research. The project aims to enhance METASPACE's utility and accelerate the adoption of spatial metabolomics, which provides unprecedented insights into the tumor microenvironment, cell-cell heterogeneity, and metabolic reprogramming in...
This Cooperative Agreement award from the National Cancer Institute (NCI), under the Federal Grant Program "Cancer Biology Research" (CFDA 93.396), provides $640,760 to The Leland Stanford Junior University to conduct comprehensive research on the fundamental biological mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) metastasis, organ tropism, and immune evasion. The key products and services to be delivered through this 5-year project include: 1) employing molecular...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $676,584.00 to The University of Texas MD Anderson Cancer Center to conduct research on the co-evolution of cancer subclones and their tumor microenvironment in metastatic triple-negative breast cancer (MTNBC). The overarching goal is to expand the fundamental understanding of MTNBC metastasis by investigating the genomic and transcriptomic evolution of primary tumor cells and their...
This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is focused on elucidating the mechanisms by which chronic psychological stress promotes cancer metastasis. The $665,155 award to The Johns Hopkins University, with a sub-award to Cold Spring Harbor Laboratory, aims to investigate the brain-body feedback loops connecting stress, the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, and the immune system that contribute to...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $700,690 to Health Research, Inc. at Roswell Park Comprehensive Cancer Center to decipher the molecular mechanisms underlying breast cancer bone metastasis. The overarching goals are to understand how the transcriptional coactivators YAP/TAZ drive the progression of microscopic to established bone metastases, and to identify new therapeutic targets to treat both early and advanced...
This federal Cooperative Agreement award for $811,500.00 from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) supports research to bridge the gap between bioinformatics and mathematical modeling for patient-specific tumor modeling. The project aims to merge bioinformatics software for analyzing single-cell and spatial multi-omics data with an agent-based modeling framework to simulate cell interactions in virtual tumor environments. Key objectives include refining a cell...
The National Cancer Institute (NCI) awarded a $510,431 Project Grant under the Cancer Biology Research (CFDA 93.396) program to The Johns Hopkins University. The grant, effective July 1, 2025 through June 30, 2030, supports comprehensive research to investigate the fundamental biological mechanisms underlying tumor dormancy, metastatic recurrence, and therapeutic resistance in aging melanoma patients. The research aims to uncover how the aging immune microenvironment influences tumor cell...