100%
Skip to main content
Platform
GovTribe AI
AI-powered insights to accelerate your government contracting workflow.
MCP Server
Connect GovTribe to your AI tools.
Beacon
Find and connect with key government decision-makers.
Profiles
Federal Agencies
Federal Contract Vehicles
Federal Grant Programs
Major Defense Acquisition Programs
NAICS Categories
PSC Categories
States
Jurisdictions
NIGP Categories
UNSPSC Categories
Vendors
Enrichment By Clearbit
Reports
New Entrants
Funding Analysis
Vehicle Analysis
Groups
Capture
Pipelines
Pursuits
Alerts
Teaming
Data
Awards
Forecasts
Federal Opportunities
State & Local Opportunities
Files
Prime and Subcontractors
Activity
Search
Exports
Solutions
Use Case
Opportunity Identification
Capture Management
Competitive Intelligence
Teaming & Partner Identification
Proposal Management
Strategic Leadership
Go-to-Market Strategy
Industry
Federal Contractors
State & Local Contractors
Grant Seekers
Government Agencies
Research & Consulting
Pricing
More
About Us
Features
Get A Demo
Sign Up
Blog
User Guide
Data Model
GovTribe for Agents
Login
Contact sales
Try for free
Login
Contact sales
Try for free
All Federal Grant Awards
Project Grant R44CA189515
Award Date
8/1/14
Completion Date
12/31/21
Dollars Obligated
$1.6M
Overview
Activity
12
Transactions
12
Subawards
Similar Awards
Federal Agency
National Cancer Institute
Awardee
Ne Scientific, Inc. (P5J4JS26KM14)
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Update #1
Update #2
AN INTRAOPERATIVE GUIDANCE PLATFORM FOR RADIO FREQUENCY ABLATION
Posted 9/8/17
5
1
2
3
Mod #
Description
ReasonForModification
Federal Obligation
Date
Not listed
AN INTRAOPERATIVE GUIDANCE PLATFORM FOR RADIO FREQUENCY ABLATION - PROJECT SUMMARY: THE OBJECTIVE OF THIS PROPOSED RESEARCH PROGRAM IS TO DEVELOP A PLATFORM FOR PLANNING AND GUIDANCE DURING RADIO FREQUENCY ABLATION (RFA). RFA IS A THERMALLY MEDIATED ABLATION TECHNIQUE, WHERE AN APPLICATOR CARRYING ONE ELECTRODE IS INSERTED INTO TUMORS PERCUTANEOUSLY (OR VIA LAPAROSCOPY, OR OPEN SURGICAL APPROACHES). RADIO FREQUENCY (RF) ENERGY IS APPLIED, DENATURATING AND COAGULATING TISSUES IN A VOLUME OF 2CM TO 5CM OF DIAMETER. SOME RFA ELECTRODES ARE SHAPED AS STRAIGHT NEEDLES; OTHERS DEPLOY AN UMBRELLA OF TINES TO ABLATE A LARGER VOLUME. RFA IS ATTRACTIVE AS IT CAN BE USED PERCUTANEOUSLY RESULTING MINIMALLY INVASIVE. RFA IS A WIDELY ACCEPTED CANCER TREATMENT THERAPY, AND IS APPLIED TO PRIMARY AND SECONDARY TUMORS IN DIFFERENT ORGANS, INCLUDING LIVER, LUNG, KIDNEY, BREAST, AND IN MUSCULOSKELETAL INTERVENTIONS. RFA IS OFTEN THE PREFERRED TREATMENT OPTION FOR INOPERABLE PATIENTS. THE TYPICAL APPROACH FOR RFA IS PERCUTANEOUS. PHYSICIANS THEREFORE HAVE NO DIRECT VIEW OF THE LOCATION OF ELECTRODES AND OF TISSUES. CT AND ULTRASOUND ARE USED INTRAOPERATIVELY TO TRACK THE LOCATION OF ELECTRODES, BUT BOTH CT AND ULTRASOUND (US) HAVE LIMITED ABILITY TO VISUALIZE THE NECROTIZATION OF TISSUES UNDER RFA. IT IS HARD THEREFORE TO ASSESS WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT. CURRENTLY PHYSICIANS RELY ON "MENTAL MAPS" OF WHERE THEY HAVE PREVIOUSLY ABLATED TISSUES AND ESTIMATE WHERE TO GO NEXT. THE NECROTIZATION VOLUME IS ALSO "MENTALLY ESTIMATED" FROM LESION GEOMETRY CHARTS PROVIDED IN PRINT BY ELECTRODE MANUFACTURERS. THESE CHARTS SHOW THE EXPECTED ABLATION GEOMETRY FOR A UNIFORM TISSUE AND DO NOT ACCOUNT FOR THE ANATOMY OR THE PRESENCE OF BLOOD VESSELS, WHICH CAN MODIFY AND REDUCE THE ABLATION VOLUME AS THEY TRANSPORT HEAT AWAY. THE OVERARCHING GOAL OF THIS PROGRAM IS TO DEVELOP A PLATFORM FOR PRE-OPERATIVE PLANNING AND INTRAOPERATIVE RFA GUIDANCE, BASED ON SIMULATION OF THE ELECTRICAL / THERMAL EFFECTS OF RFA AND REAL-TIME INTRAOPERATIVE PREDICTION OF NECROTIZATION PATTERNS. IMAGE FUSION OF RFA SIMULATIONS ONTO CT INTRAOPERATIVE IMAGES WOULD CONSTITUTE A GUIDANCE SYSTEM ABLE TO SHOW WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT, ALLOWING THE PHYSICIANS TO PROPERLY REPOSITIONS ELECTRODES AND ACHIEVE CONSISTENT OVERLAP. THIS WOULD IMPROVE OUTCOMES OF RFA PARTICULARLY FOR PATIENTS WITH TUMORS GREATER THAN 2CM, FOR WHICH TOTAL NECROTIZATION HAS BEEN SHOWN TO BE PARTICULARLY HARD TO ACHIEVE WITHOUT GUIDANCE.
$0
5/6/22
Not listed
AN INTRAOPERATIVE GUIDANCE PLATFORM FOR RADIO FREQUENCY ABLATION - PROJECT SUMMARY: THE OBJECTIVE OF THIS PROPOSED RESEARCH PROGRAM IS TO DEVELOP A PLATFORM FOR PLANNING AND GUIDANCE DURING RADIO FREQUENCY ABLATION (RFA). RFA IS A THERMALLY MEDIATED ABLATION TECHNIQUE, WHERE AN APPLICATOR CARRYING ONE ELECTRODE IS INSERTED INTO TUMORS PERCUTANEOUSLY (OR VIA LAPAROSCOPY, OR OPEN SURGICAL APPROACHES). RADIO FREQUENCY (RF) ENERGY IS APPLIED, DENATURATING AND COAGULATING TISSUES IN A VOLUME OF 2CM TO 5CM OF DIAMETER. SOME RFA ELECTRODES ARE SHAPED AS STRAIGHT NEEDLES; OTHERS DEPLOY AN UMBRELLA OF TINES TO ABLATE A LARGER VOLUME. RFA IS ATTRACTIVE AS IT CAN BE USED PERCUTANEOUSLY RESULTING MINIMALLY INVASIVE. RFA IS A WIDELY ACCEPTED CANCER TREATMENT THERAPY, AND IS APPLIED TO PRIMARY AND SECONDARY TUMORS IN DIFFERENT ORGANS, INCLUDING LIVER, LUNG, KIDNEY, BREAST, AND IN MUSCULOSKELETAL INTERVENTIONS. RFA IS OFTEN THE PREFERRED TREATMENT OPTION FOR INOPERABLE PATIENTS. THE TYPICAL APPROACH FOR RFA IS PERCUTANEOUS. PHYSICIANS THEREFORE HAVE NO DIRECT VIEW OF THE LOCATION OF ELECTRODES AND OF TISSUES. CT AND ULTRASOUND ARE USED INTRAOPERATIVELY TO TRACK THE LOCATION OF ELECTRODES, BUT BOTH CT AND ULTRASOUND (US) HAVE LIMITED ABILITY TO VISUALIZE THE NECROTIZATION OF TISSUES UNDER RFA. IT IS HARD THEREFORE TO ASSESS WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT. CURRENTLY PHYSICIANS RELY ON "MENTAL MAPS" OF WHERE THEY HAVE PREVIOUSLY ABLATED TISSUES AND ESTIMATE WHERE TO GO NEXT. THE NECROTIZATION VOLUME IS ALSO "MENTALLY ESTIMATED" FROM LESION GEOMETRY CHARTS PROVIDED IN PRINT BY ELECTRODE MANUFACTURERS. THESE CHARTS SHOW THE EXPECTED ABLATION GEOMETRY FOR A UNIFORM TISSUE AND DO NOT ACCOUNT FOR THE ANATOMY OR THE PRESENCE OF BLOOD VESSELS, WHICH CAN MODIFY AND REDUCE THE ABLATION VOLUME AS THEY TRANSPORT HEAT AWAY. THE OVERARCHING GOAL OF THIS PROGRAM IS TO DEVELOP A PLATFORM FOR PRE-OPERATIVE PLANNING AND INTRAOPERATIVE RFA GUIDANCE, BASED ON SIMULATION OF THE ELECTRICAL / THERMAL EFFECTS OF RFA AND REAL-TIME INTRAOPERATIVE PREDICTION OF NECROTIZATION PATTERNS. IMAGE FUSION OF RFA SIMULATIONS ONTO CT INTRAOPERATIVE IMAGES WOULD CONSTITUTE A GUIDANCE SYSTEM ABLE TO SHOW WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT, ALLOWING THE PHYSICIANS TO PROPERLY REPOSITIONS ELECTRODES AND ACHIEVE CONSISTENT OVERLAP. THIS WOULD IMPROVE OUTCOMES OF RFA PARTICULARLY FOR PATIENTS WITH TUMORS GREATER THAN 2CM, FOR WHICH TOTAL NECROTIZATION HAS BEEN SHOWN TO BE PARTICULARLY HARD TO ACHIEVE WITHOUT GUIDANCE.
$0
5/6/22
Not listed
AN INTRAOPERATIVE GUIDANCE PLATFORM FOR RADIO FREQUENCY ABLATION - PROJECT SUMMARY: THE OBJECTIVE OF THIS PROPOSED RESEARCH PROGRAM IS TO DEVELOP A PLATFORM FOR PLANNING AND GUIDANCE DURING RADIO FREQUENCY ABLATION (RFA). RFA IS A THERMALLY MEDIATED ABLATION TECHNIQUE, WHERE AN APPLICATOR CARRYING ONE ELECTRODE IS INSERTED INTO TUMORS PERCUTANEOUSLY (OR VIA LAPAROSCOPY, OR OPEN SURGICAL APPROACHES). RADIO FREQUENCY (RF) ENERGY IS APPLIED, DENATURATING AND COAGULATING TISSUES IN A VOLUME OF 2CM TO 5CM OF DIAMETER. SOME RFA ELECTRODES ARE SHAPED AS STRAIGHT NEEDLES; OTHERS DEPLOY AN UMBRELLA OF TINES TO ABLATE A LARGER VOLUME. RFA IS ATTRACTIVE AS IT CAN BE USED PERCUTANEOUSLY RESULTING MINIMALLY INVASIVE. RFA IS A WIDELY ACCEPTED CANCER TREATMENT THERAPY, AND IS APPLIED TO PRIMARY AND SECONDARY TUMORS IN DIFFERENT ORGANS, INCLUDING LIVER, LUNG, KIDNEY, BREAST, AND IN MUSCULOSKELETAL INTERVENTIONS. RFA IS OFTEN THE PREFERRED TREATMENT OPTION FOR INOPERABLE PATIENTS. THE TYPICAL APPROACH FOR RFA IS PERCUTANEOUS. PHYSICIANS THEREFORE HAVE NO DIRECT VIEW OF THE LOCATION OF ELECTRODES AND OF TISSUES. CT AND ULTRASOUND ARE USED INTRAOPERATIVELY TO TRACK THE LOCATION OF ELECTRODES, BUT BOTH CT AND ULTRASOUND (US) HAVE LIMITED ABILITY TO VISUALIZE THE NECROTIZATION OF TISSUES UNDER RFA. IT IS HARD THEREFORE TO ASSESS WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT. CURRENTLY PHYSICIANS RELY ON "MENTAL MAPS" OF WHERE THEY HAVE PREVIOUSLY ABLATED TISSUES AND ESTIMATE WHERE TO GO NEXT. THE NECROTIZATION VOLUME IS ALSO "MENTALLY ESTIMATED" FROM LESION GEOMETRY CHARTS PROVIDED IN PRINT BY ELECTRODE MANUFACTURERS. THESE CHARTS SHOW THE EXPECTED ABLATION GEOMETRY FOR A UNIFORM TISSUE AND DO NOT ACCOUNT FOR THE ANATOMY OR THE PRESENCE OF BLOOD VESSELS, WHICH CAN MODIFY AND REDUCE THE ABLATION VOLUME AS THEY TRANSPORT HEAT AWAY. THE OVERARCHING GOAL OF THIS PROGRAM IS TO DEVELOP A PLATFORM FOR PRE-OPERATIVE PLANNING AND INTRAOPERATIVE RFA GUIDANCE, BASED ON SIMULATION OF THE ELECTRICAL / THERMAL EFFECTS OF RFA AND REAL-TIME INTRAOPERATIVE PREDICTION OF NECROTIZATION PATTERNS. IMAGE FUSION OF RFA SIMULATIONS ONTO CT INTRAOPERATIVE IMAGES WOULD CONSTITUTE A GUIDANCE SYSTEM ABLE TO SHOW WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT, ALLOWING THE PHYSICIANS TO PROPERLY REPOSITIONS ELECTRODES AND ACHIEVE CONSISTENT OVERLAP. THIS WOULD IMPROVE OUTCOMES OF RFA PARTICULARLY FOR PATIENTS WITH TUMORS GREATER THAN 2CM, FOR WHICH TOTAL NECROTIZATION HAS BEEN SHOWN TO BE PARTICULARLY HARD TO ACHIEVE WITHOUT GUIDANCE.
$0
7/14/21
Not listed
AN INTRAOPERATIVE GUIDANCE PLATFORM FOR RADIO FREQUENCY ABLATION - PROJECT SUMMARY: THE OBJECTIVE OF THIS PROPOSED RESEARCH PROGRAM IS TO DEVELOP A PLATFORM FOR PLANNING AND GUIDANCE DURING RADIO FREQUENCY ABLATION (RFA). RFA IS A THERMALLY MEDIATED ABLATION TECHNIQUE, WHERE AN APPLICATOR CARRYING ONE ELECTRODE IS INSERTED INTO TUMORS PERCUTANEOUSLY (OR VIA LAPAROSCOPY, OR OPEN SURGICAL APPROACHES). RADIO FREQUENCY (RF) ENERGY IS APPLIED, DENATURATING AND COAGULATING TISSUES IN A VOLUME OF 2CM TO 5CM OF DIAMETER. SOME RFA ELECTRODES ARE SHAPED AS STRAIGHT NEEDLES; OTHERS DEPLOY AN UMBRELLA OF TINES TO ABLATE A LARGER VOLUME. RFA IS ATTRACTIVE AS IT CAN BE USED PERCUTANEOUSLY RESULTING MINIMALLY INVASIVE. RFA IS A WIDELY ACCEPTED CANCER TREATMENT THERAPY, AND IS APPLIED TO PRIMARY AND SECONDARY TUMORS IN DIFFERENT ORGANS, INCLUDING LIVER, LUNG, KIDNEY, BREAST, AND IN MUSCULOSKELETAL INTERVENTIONS. RFA IS OFTEN THE PREFERRED TREATMENT OPTION FOR INOPERABLE PATIENTS. THE TYPICAL APPROACH FOR RFA IS PERCUTANEOUS. PHYSICIANS THEREFORE HAVE NO DIRECT VIEW OF THE LOCATION OF ELECTRODES AND OF TISSUES. CT AND ULTRASOUND ARE USED INTRAOPERATIVELY TO TRACK THE LOCATION OF ELECTRODES, BUT BOTH CT AND ULTRASOUND (US) HAVE LIMITED ABILITY TO VISUALIZE THE NECROTIZATION OF TISSUES UNDER RFA. IT IS HARD THEREFORE TO ASSESS WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT. CURRENTLY PHYSICIANS RELY ON "MENTAL MAPS" OF WHERE THEY HAVE PREVIOUSLY ABLATED TISSUES AND ESTIMATE WHERE TO GO NEXT. THE NECROTIZATION VOLUME IS ALSO "MENTALLY ESTIMATED" FROM LESION GEOMETRY CHARTS PROVIDED IN PRINT BY ELECTRODE MANUFACTURERS. THESE CHARTS SHOW THE EXPECTED ABLATION GEOMETRY FOR A UNIFORM TISSUE AND DO NOT ACCOUNT FOR THE ANATOMY OR THE PRESENCE OF BLOOD VESSELS, WHICH CAN MODIFY AND REDUCE THE ABLATION VOLUME AS THEY TRANSPORT HEAT AWAY. THE OVERARCHING GOAL OF THIS PROGRAM IS TO DEVELOP A PLATFORM FOR PRE-OPERATIVE PLANNING AND INTRAOPERATIVE RFA GUIDANCE, BASED ON SIMULATION OF THE ELECTRICAL / THERMAL EFFECTS OF RFA AND REAL-TIME INTRAOPERATIVE PREDICTION OF NECROTIZATION PATTERNS. IMAGE FUSION OF RFA SIMULATIONS ONTO CT INTRAOPERATIVE IMAGES WOULD CONSTITUTE A GUIDANCE SYSTEM ABLE TO SHOW WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT, ALLOWING THE PHYSICIANS TO PROPERLY REPOSITIONS ELECTRODES AND ACHIEVE CONSISTENT OVERLAP. THIS WOULD IMPROVE OUTCOMES OF RFA PARTICULARLY FOR PATIENTS WITH TUMORS GREATER THAN 2CM, FOR WHICH TOTAL NECROTIZATION HAS BEEN SHOWN TO BE PARTICULARLY HARD TO ACHIEVE WITHOUT GUIDANCE.
$0
7/14/21
Not listed
AN INTRAOPERATIVE GUIDANCE PLATFORM FOR RADIO FREQUENCY ABLATION - PROJECT SUMMARY: THE OBJECTIVE OF THIS PROPOSED RESEARCH PROGRAM IS TO DEVELOP A PLATFORM FOR PLANNING AND GUIDANCE DURING RADIO FREQUENCY ABLATION (RFA). RFA IS A THERMALLY MEDIATED ABLATION TECHNIQUE, WHERE AN APPLICATOR CARRYING ONE ELECTRODE IS INSERTED INTO TUMORS PERCUTANEOUSLY (OR VIA LAPAROSCOPY, OR OPEN SURGICAL APPROACHES). RADIO FREQUENCY (RF) ENERGY IS APPLIED, DENATURATING AND COAGULATING TISSUES IN A VOLUME OF 2CM TO 5CM OF DIAMETER. SOME RFA ELECTRODES ARE SHAPED AS STRAIGHT NEEDLES; OTHERS DEPLOY AN UMBRELLA OF TINES TO ABLATE A LARGER VOLUME. RFA IS ATTRACTIVE AS IT CAN BE USED PERCUTANEOUSLY RESULTING MINIMALLY INVASIVE. RFA IS A WIDELY ACCEPTED CANCER TREATMENT THERAPY, AND IS APPLIED TO PRIMARY AND SECONDARY TUMORS IN DIFFERENT ORGANS, INCLUDING LIVER, LUNG, KIDNEY, BREAST, AND IN MUSCULOSKELETAL INTERVENTIONS. RFA IS OFTEN THE PREFERRED TREATMENT OPTION FOR INOPERABLE PATIENTS. THE TYPICAL APPROACH FOR RFA IS PERCUTANEOUS. PHYSICIANS THEREFORE HAVE NO DIRECT VIEW OF THE LOCATION OF ELECTRODES AND OF TISSUES. CT AND ULTRASOUND ARE USED INTRAOPERATIVELY TO TRACK THE LOCATION OF ELECTRODES, BUT BOTH CT AND ULTRASOUND (US) HAVE LIMITED ABILITY TO VISUALIZE THE NECROTIZATION OF TISSUES UNDER RFA. IT IS HARD THEREFORE TO ASSESS WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT. CURRENTLY PHYSICIANS RELY ON "MENTAL MAPS" OF WHERE THEY HAVE PREVIOUSLY ABLATED TISSUES AND ESTIMATE WHERE TO GO NEXT. THE NECROTIZATION VOLUME IS ALSO "MENTALLY ESTIMATED" FROM LESION GEOMETRY CHARTS PROVIDED IN PRINT BY ELECTRODE MANUFACTURERS. THESE CHARTS SHOW THE EXPECTED ABLATION GEOMETRY FOR A UNIFORM TISSUE AND DO NOT ACCOUNT FOR THE ANATOMY OR THE PRESENCE OF BLOOD VESSELS, WHICH CAN MODIFY AND REDUCE THE ABLATION VOLUME AS THEY TRANSPORT HEAT AWAY. THE OVERARCHING GOAL OF THIS PROGRAM IS TO DEVELOP A PLATFORM FOR PRE-OPERATIVE PLANNING AND INTRAOPERATIVE RFA GUIDANCE, BASED ON SIMULATION OF THE ELECTRICAL / THERMAL EFFECTS OF RFA AND REAL-TIME INTRAOPERATIVE PREDICTION OF NECROTIZATION PATTERNS. IMAGE FUSION OF RFA SIMULATIONS ONTO CT INTRAOPERATIVE IMAGES WOULD CONSTITUTE A GUIDANCE SYSTEM ABLE TO SHOW WHICH TISSUES HAVE BEEN TREATED AND WHICH NOT, ALLOWING THE PHYSICIANS TO PROPERLY REPOSITIONS ELECTRODES AND ACHIEVE CONSISTENT OVERLAP. THIS WOULD IMPROVE OUTCOMES OF RFA PARTICULARLY FOR PATIENTS WITH TUMORS GREATER THAN 2CM, FOR WHICH TOTAL NECROTIZATION HAS BEEN SHOWN TO BE PARTICULARLY HARD TO ACHIEVE WITHOUT GUIDANCE.
$0
7/8/21